Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design
Само за регистроване кориснике
2014
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
ObjectivesThis study investigates the application of hot-melt extrusion for the formulation of carbamazepine (CBZ) solid dispersions, using polyethyleneglycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus, BASF, Germany) and polyoxyethylene-polyoxypropylene block copolymer (Poloxamer 407). In agreement with the current Quality by Design principle, formulations of solid dispersions were prepared according to a D-optimal mixture experimental design, and the influence of formulation composition on the properties of the dispersions (CBZ heat of fusion and release rate) was estimated. MethodsPrepared solid dispersions were characterized using differential scanning calorimetry, attenuated total reflectance infrared spectroscopy and hot stage microscopy, as well as by determination of the dissolution rate of CBZ from the hot-melt extrudates. Key findingsSolid dispersions of CBZ can be successfully prepared using the novel copolymer Soluplus. Inclusion of Poloxamer 407 as... a plasticizer facilitated the processing and decreased the hardness of hot-melt extrudates. Regardless of their composition, all hot-melt extrudates displayed an improvement in the release rate compared to the pure CBZ, with formulations having the ratio of CBZ:Poloxamer 407=1:1 showing the highest increase in CBZ release rate. ConclusionsInteractions between the mixture components (CBZ and polymers), or quadratic effects of the components, play a significant role in overall influence on the CBZ release rate.
Кључне речи:
carbamazepine / mixture design / Poloxamer 407 / solid dispersion / SoluplusИзвор:
Journal of Pharmacy and Pharmacology, 2014, 66, 2, 232-243Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Развој производа и технологија које обезбеђују жељено ослобађање лековитих супстанци из чврстих фармацеутских облика (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1111/jphp.12199
ISSN: 0022-3573
PubMed: 24350884
WoS: 000329753300007
Scopus: 2-s2.0-84892766139
Институција/група
PharmacyTY - JOUR AU - Đuriš, Jelena AU - Ioannis, Nikolakakis AU - Ibrić, Svetlana AU - Đurić, Zorica AU - Kachrimanis, Kyriakos PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2185 AB - ObjectivesThis study investigates the application of hot-melt extrusion for the formulation of carbamazepine (CBZ) solid dispersions, using polyethyleneglycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus, BASF, Germany) and polyoxyethylene-polyoxypropylene block copolymer (Poloxamer 407). In agreement with the current Quality by Design principle, formulations of solid dispersions were prepared according to a D-optimal mixture experimental design, and the influence of formulation composition on the properties of the dispersions (CBZ heat of fusion and release rate) was estimated. MethodsPrepared solid dispersions were characterized using differential scanning calorimetry, attenuated total reflectance infrared spectroscopy and hot stage microscopy, as well as by determination of the dissolution rate of CBZ from the hot-melt extrudates. Key findingsSolid dispersions of CBZ can be successfully prepared using the novel copolymer Soluplus. Inclusion of Poloxamer 407 as a plasticizer facilitated the processing and decreased the hardness of hot-melt extrudates. Regardless of their composition, all hot-melt extrudates displayed an improvement in the release rate compared to the pure CBZ, with formulations having the ratio of CBZ:Poloxamer 407=1:1 showing the highest increase in CBZ release rate. ConclusionsInteractions between the mixture components (CBZ and polymers), or quadratic effects of the components, play a significant role in overall influence on the CBZ release rate. PB - Wiley-Blackwell, Hoboken T2 - Journal of Pharmacy and Pharmacology T1 - Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design VL - 66 IS - 2 SP - 232 EP - 243 DO - 10.1111/jphp.12199 ER -
@article{ author = "Đuriš, Jelena and Ioannis, Nikolakakis and Ibrić, Svetlana and Đurić, Zorica and Kachrimanis, Kyriakos", year = "2014", abstract = "ObjectivesThis study investigates the application of hot-melt extrusion for the formulation of carbamazepine (CBZ) solid dispersions, using polyethyleneglycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus, BASF, Germany) and polyoxyethylene-polyoxypropylene block copolymer (Poloxamer 407). In agreement with the current Quality by Design principle, formulations of solid dispersions were prepared according to a D-optimal mixture experimental design, and the influence of formulation composition on the properties of the dispersions (CBZ heat of fusion and release rate) was estimated. MethodsPrepared solid dispersions were characterized using differential scanning calorimetry, attenuated total reflectance infrared spectroscopy and hot stage microscopy, as well as by determination of the dissolution rate of CBZ from the hot-melt extrudates. Key findingsSolid dispersions of CBZ can be successfully prepared using the novel copolymer Soluplus. Inclusion of Poloxamer 407 as a plasticizer facilitated the processing and decreased the hardness of hot-melt extrudates. Regardless of their composition, all hot-melt extrudates displayed an improvement in the release rate compared to the pure CBZ, with formulations having the ratio of CBZ:Poloxamer 407=1:1 showing the highest increase in CBZ release rate. ConclusionsInteractions between the mixture components (CBZ and polymers), or quadratic effects of the components, play a significant role in overall influence on the CBZ release rate.", publisher = "Wiley-Blackwell, Hoboken", journal = "Journal of Pharmacy and Pharmacology", title = "Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design", volume = "66", number = "2", pages = "232-243", doi = "10.1111/jphp.12199" }
Đuriš, J., Ioannis, N., Ibrić, S., Đurić, Z.,& Kachrimanis, K.. (2014). Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design. in Journal of Pharmacy and Pharmacology Wiley-Blackwell, Hoboken., 66(2), 232-243. https://doi.org/10.1111/jphp.12199
Đuriš J, Ioannis N, Ibrić S, Đurić Z, Kachrimanis K. Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design. in Journal of Pharmacy and Pharmacology. 2014;66(2):232-243. doi:10.1111/jphp.12199 .
Đuriš, Jelena, Ioannis, Nikolakakis, Ibrić, Svetlana, Đurić, Zorica, Kachrimanis, Kyriakos, "Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design" in Journal of Pharmacy and Pharmacology, 66, no. 2 (2014):232-243, https://doi.org/10.1111/jphp.12199 . .