New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
Само за регистроване кориснике
1999
Аутори
Jovanović, MSBrborić, Jasmina
Vladimirov, S
Zmbova, B
Vuksanović, LJ
Živanov-Stakić, Dobrila
Obradović, V
Информативни прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
Извор:
Journal of Radioanalytical and Nuclear Chemistry, 1999, 240, 1, 321-324Издавач:
- Springer
- Elsevier Science B. V., Amsterdam
DOI: 10.1007/BF02349171
ISSN: 0236-5731
WoS: 000080027500044
Scopus: 2-s2.0-0032960102
Институција/група
PharmacyTY - JOUR AU - Jovanović, MS AU - Brborić, Jasmina AU - Vladimirov, S AU - Zmbova, B AU - Vuksanović, LJ AU - Živanov-Stakić, Dobrila AU - Obradović, V PY - 1999 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/219 AB - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives. PB - Springer PB - Elsevier Science B. V., Amsterdam T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging VL - 240 IS - 1 SP - 321 EP - 324 DO - 10.1007/BF02349171 ER -
@article{ author = "Jovanović, MS and Brborić, Jasmina and Vladimirov, S and Zmbova, B and Vuksanović, LJ and Živanov-Stakić, Dobrila and Obradović, V", year = "1999", abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.", publisher = "Springer, Elsevier Science B. V., Amsterdam", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging", volume = "240", number = "1", pages = "321-324", doi = "10.1007/BF02349171" }
Jovanović, M., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanović, L., Živanov-Stakić, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry Springer., 240(1), 321-324. https://doi.org/10.1007/BF02349171
Jovanović M, Brborić J, Vladimirov S, Zmbova B, Vuksanović L, Živanov-Stakić D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324. doi:10.1007/BF02349171 .
Jovanović, MS, Brborić, Jasmina, Vladimirov, S, Zmbova, B, Vuksanović, LJ, Živanov-Stakić, Dobrila, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324, https://doi.org/10.1007/BF02349171 . .