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New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
dc.creator | Jovanović, MS | |
dc.creator | Brborić, Jasmina | |
dc.creator | Vladimirov, S | |
dc.creator | Zmbova, B | |
dc.creator | Vuksanović, LJ | |
dc.creator | Živanov-Stakić, Dobrila | |
dc.creator | Obradović, V | |
dc.date.accessioned | 2019-09-02T10:51:29Z | |
dc.date.available | 2019-09-02T10:51:29Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 0236-5731 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/219 | |
dc.description.abstract | A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives. | en |
dc.publisher | Springer | |
dc.publisher | Elsevier Science B. V., Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Journal of Radioanalytical and Nuclear Chemistry | |
dc.title | New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging | en |
dc.type | contributionToPeriodical | |
dc.rights.license | ARR | |
dcterms.abstract | Јовановић, МС; Брборић, Јасмина; Владимиров, С; Живанов-Стакић, Добрила; Змбова, Б; Вуксановић, ЛЈ; Обрадовић, В; | |
dc.citation.volume | 240 | |
dc.citation.issue | 1 | |
dc.citation.spage | 321 | |
dc.citation.epage | 324 | |
dc.citation.other | 240(1): 321-324 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000080027500044 | |
dc.identifier.doi | 10.1007/BF02349171 | |
dc.identifier.scopus | 2-s2.0-0032960102 | |
dc.type.version | publishedVersion |