Приказ основних података о документу

dc.creatorTomić, Maja
dc.creatorPecikoza, Uroš
dc.creatorMicov, Ana
dc.creatorPopović, Božidar V.
dc.creatorStepanović-Petrović, Radica
dc.date.accessioned2019-09-02T11:46:35Z
dc.date.available2019-09-02T11:46:35Z
dc.date.issued2015
dc.identifier.issn0003-2999
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2385
dc.description.abstractBACKGROUND: Levetiracetam is an antiepileptic drug with analgesic efficacy shown in pain models and small clinical trials. Sumatriptan is used in acute migraine treatment. Caffeine is widely consumed in some beverages/foods and is also an adjuvant in analgesic formulations. We examined the effects of systemic levetiracetam, sumatriptan, and caffeine and their interactions in 2-component combinations in the rat orofacial formalin test, a model of trigeminal pain. METHODS: Rats received a subcutaneous injection of formalin solution into the perinasal area, and the total time spent in nociceptive behavior (face rubbing) was quantified. The antinociceptive effect of drugs/drug combinations was assessed 1 hour after per os administration. The type of interaction between levetiracetam/sumatriptan and caffeine was examined by comparing the effects of a fixed, effective dose of levetiracetam/sumatriptan alone with the effects of the same dose applied with increasing, subeffective doses of caffeine. The type of interaction between levetiracetam and sumatriptan was determined by isobolographic analysis. RESULTS: Levetiracetam (1-50 mg/kg) and sumatriptan (0.5-5 mg/kg) produced significant and dose-dependent antinociceptive effects in both phases of the orofacial formalin test (P = 0.001). Caffeine (7.5-100 mg/kg) produced significant antinociception in the second phase of the test (P = 0.04). Caffeine (1-7.5 mg/kg) significantly reduced the antinociceptive effects of levetiracetam (25 mg/kg) (first phase P = 0.002, second phase P lt 0.001) and sumatriptan (2.5 mg/kg) (first phase P = 0.014, second phase P = 0.027); dose-dependent inhibition was observed in the second phase. Levetiracetam and sumatriptan exerted an additive interaction in the second phase of the orofacial formalin test. CONCLUSIONS: Results indicate that levetiracetam may be useful for treatment of pain in the trigeminal region. Dietary caffeine might decrease the effects of levetiracetam and sumatriptan; this needs to be considered in clinical settings. A levetiracetam-sumatriptan combination could also be useful in trigeminal pain treatment. Its efficacy and adverse effects should be examined clinically.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//
dc.rightsrestrictedAccess
dc.sourceAnesthesia and Analgesia
dc.titleThe Effects of Levetiracetam, Sumatriptan, and Caffeine in a Rat Model of Trigeminal Pain: Interactions in 2-Component Combinationsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтепановић-Петровић, Радица; Томић, Маја; Мицов, Aна; Поповић, Божидар В.; Пецикоза, Урош;
dc.citation.volume120
dc.citation.issue6
dc.citation.spage1385
dc.citation.epage1393
dc.citation.other120(6): 1385-1393
dc.citation.rankaM21
dc.identifier.wos000354864100030
dc.identifier.doi10.1213/ANE.0000000000000640
dc.identifier.pmid25710675
dc.identifier.scopus2-s2.0-84937920174
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу