Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Besides being important occupational hazards, lead and cadmium are nowadays metals of great environmental concern. Both metals, without any physiological functions, can induce serious adverse health effects in various organs and tissues. Although Pb and Cd are non-redox metals, one of the important mechanisms underlying their toxicity is oxidative stress induction as a result of the generation of reactive species and/or depletion of the antioxidant defense system. Considering that the co-exposure to both metals is a much more realistic scenario, the effects of these metals on oxidative status when simultaneously present in the organism have become one of the contemporary issues in toxicology. This paper reviews short and long term studies conducted on Pb or Cd-induced oxidative stress in blood, liver and kidneys as the most prominent target organs of the toxicity of these metals and proposes the possible molecular mechanisms of the observed effects. The review is also focused on the re...sults obtained for the effects of the combined treatment with Pb and Cd on oxidative status in target organs and on the mechanisms of their possible interactions.
Кључне речи:
Lead / Cadmium / Mixture / Intoxication / Oxidative stressИзвор:
Food and Chemical Toxicology, 2015, 78, 130-140Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Унапређење и развој хигијенских и технолошких поступака у производњи намирница животињског порекла у циљу добијања квалитетних и безбедних производа конкурентних на светском тржишту (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
DOI: 10.1016/jict.2015.02.011
ISSN: 0278-6915
PubMed: 25681546
WoS: 000352663400017
Scopus: 2-s2.0-84923328721
Институција/група
PharmacyTY - JOUR AU - Matović, Vesna AU - Buha, Aleksandra AU - Đukić-Ćosić, Danijela AU - Bulat, Zorica PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2387 AB - Besides being important occupational hazards, lead and cadmium are nowadays metals of great environmental concern. Both metals, without any physiological functions, can induce serious adverse health effects in various organs and tissues. Although Pb and Cd are non-redox metals, one of the important mechanisms underlying their toxicity is oxidative stress induction as a result of the generation of reactive species and/or depletion of the antioxidant defense system. Considering that the co-exposure to both metals is a much more realistic scenario, the effects of these metals on oxidative status when simultaneously present in the organism have become one of the contemporary issues in toxicology. This paper reviews short and long term studies conducted on Pb or Cd-induced oxidative stress in blood, liver and kidneys as the most prominent target organs of the toxicity of these metals and proposes the possible molecular mechanisms of the observed effects. The review is also focused on the results obtained for the effects of the combined treatment with Pb and Cd on oxidative status in target organs and on the mechanisms of their possible interactions. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Food and Chemical Toxicology T1 - Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys VL - 78 SP - 130 EP - 140 DO - 10.1016/jict.2015.02.011 ER -
@article{ author = "Matović, Vesna and Buha, Aleksandra and Đukić-Ćosić, Danijela and Bulat, Zorica", year = "2015", abstract = "Besides being important occupational hazards, lead and cadmium are nowadays metals of great environmental concern. Both metals, without any physiological functions, can induce serious adverse health effects in various organs and tissues. Although Pb and Cd are non-redox metals, one of the important mechanisms underlying their toxicity is oxidative stress induction as a result of the generation of reactive species and/or depletion of the antioxidant defense system. Considering that the co-exposure to both metals is a much more realistic scenario, the effects of these metals on oxidative status when simultaneously present in the organism have become one of the contemporary issues in toxicology. This paper reviews short and long term studies conducted on Pb or Cd-induced oxidative stress in blood, liver and kidneys as the most prominent target organs of the toxicity of these metals and proposes the possible molecular mechanisms of the observed effects. The review is also focused on the results obtained for the effects of the combined treatment with Pb and Cd on oxidative status in target organs and on the mechanisms of their possible interactions.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Food and Chemical Toxicology", title = "Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys", volume = "78", pages = "130-140", doi = "10.1016/jict.2015.02.011" }
Matović, V., Buha, A., Đukić-Ćosić, D.,& Bulat, Z.. (2015). Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys. in Food and Chemical Toxicology Pergamon-Elsevier Science Ltd, Oxford., 78, 130-140. https://doi.org/10.1016/jict.2015.02.011
Matović V, Buha A, Đukić-Ćosić D, Bulat Z. Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys. in Food and Chemical Toxicology. 2015;78:130-140. doi:10.1016/jict.2015.02.011 .
Matović, Vesna, Buha, Aleksandra, Đukić-Ćosić, Danijela, Bulat, Zorica, "Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys" in Food and Chemical Toxicology, 78 (2015):130-140, https://doi.org/10.1016/jict.2015.02.011 . .