Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety
Samo za registrovane korisnike
2016
Autori
Angelova, Violina T.Vassilev, Nikolay G.
Nikolova-Mladenova, Boryana
Vitas, Jasmina
Malbasa, Radomir
Momekov, Georgi
Đukić, Mirjana
Saso, Luciano
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysis. The nuclear magnetic resonance spectra of the hydrazones 4a-c showed exchange of syn and antiperiplanar conformers around the amide bond, the more stable being the antiperiplanar one. The nuclear Overhauser effect spectroscopy (NOESY) spectra confirm E configuration around C=N bond. The tested compounds exhibited concentration-dependent cytotoxic effects against human tumor cell lines in a micromolar range (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay). Hydrazone 4a proved to be the most potent antiproliferative agent of the series. Within the antioxidant screening 8b exhibited the highest radical scavenging activity (% RSA max) and the largest rate constant for the reaction with 2,2-diphenyl-1-picrylhydrazyl.
Izvor:
Medicinal Chemistry Research, 2016, 25, 9, 2082-2092Izdavač:
- Springer Birkhauser, New York
Finansiranje / projekti:
- National Research Fund of Bulgaria - UNA-17/2005
DOI: 10.1007/s00044-016-1661-4
ISSN: 1054-2523
WoS: 000385175500030
Scopus: 2-s2.0-84979586929
Institucija/grupa
PharmacyTY - JOUR AU - Angelova, Violina T. AU - Vassilev, Nikolay G. AU - Nikolova-Mladenova, Boryana AU - Vitas, Jasmina AU - Malbasa, Radomir AU - Momekov, Georgi AU - Đukić, Mirjana AU - Saso, Luciano PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2760 AB - A series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysis. The nuclear magnetic resonance spectra of the hydrazones 4a-c showed exchange of syn and antiperiplanar conformers around the amide bond, the more stable being the antiperiplanar one. The nuclear Overhauser effect spectroscopy (NOESY) spectra confirm E configuration around C=N bond. The tested compounds exhibited concentration-dependent cytotoxic effects against human tumor cell lines in a micromolar range (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay). Hydrazone 4a proved to be the most potent antiproliferative agent of the series. Within the antioxidant screening 8b exhibited the highest radical scavenging activity (% RSA max) and the largest rate constant for the reaction with 2,2-diphenyl-1-picrylhydrazyl. PB - Springer Birkhauser, New York T2 - Medicinal Chemistry Research T1 - Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety VL - 25 IS - 9 SP - 2082 EP - 2092 DO - 10.1007/s00044-016-1661-4 ER -
@article{ author = "Angelova, Violina T. and Vassilev, Nikolay G. and Nikolova-Mladenova, Boryana and Vitas, Jasmina and Malbasa, Radomir and Momekov, Georgi and Đukić, Mirjana and Saso, Luciano", year = "2016", abstract = "A series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysis. The nuclear magnetic resonance spectra of the hydrazones 4a-c showed exchange of syn and antiperiplanar conformers around the amide bond, the more stable being the antiperiplanar one. The nuclear Overhauser effect spectroscopy (NOESY) spectra confirm E configuration around C=N bond. The tested compounds exhibited concentration-dependent cytotoxic effects against human tumor cell lines in a micromolar range (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay). Hydrazone 4a proved to be the most potent antiproliferative agent of the series. Within the antioxidant screening 8b exhibited the highest radical scavenging activity (% RSA max) and the largest rate constant for the reaction with 2,2-diphenyl-1-picrylhydrazyl.", publisher = "Springer Birkhauser, New York", journal = "Medicinal Chemistry Research", title = "Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety", volume = "25", number = "9", pages = "2082-2092", doi = "10.1007/s00044-016-1661-4" }
Angelova, V. T., Vassilev, N. G., Nikolova-Mladenova, B., Vitas, J., Malbasa, R., Momekov, G., Đukić, M.,& Saso, L.. (2016). Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety. in Medicinal Chemistry Research Springer Birkhauser, New York., 25(9), 2082-2092. https://doi.org/10.1007/s00044-016-1661-4
Angelova VT, Vassilev NG, Nikolova-Mladenova B, Vitas J, Malbasa R, Momekov G, Đukić M, Saso L. Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety. in Medicinal Chemistry Research. 2016;25(9):2082-2092. doi:10.1007/s00044-016-1661-4 .
Angelova, Violina T., Vassilev, Nikolay G., Nikolova-Mladenova, Boryana, Vitas, Jasmina, Malbasa, Radomir, Momekov, Georgi, Đukić, Mirjana, Saso, Luciano, "Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety" in Medicinal Chemistry Research, 25, no. 9 (2016):2082-2092, https://doi.org/10.1007/s00044-016-1661-4 . .