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Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea
dc.creator | Vekić, Jelena | |
dc.creator | Joppa, Pavol | |
dc.creator | Habalova, Viera | |
dc.creator | Tisko, Radovan | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Pobeha, Pavol | |
dc.creator | Gojković, Tamara | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Strbova, Zuzana | |
dc.creator | Kuklisova, Zuzana | |
dc.creator | Slaba, Eva | |
dc.creator | Rizzo, Manfredi | |
dc.creator | Tkacova, Ruzena | |
dc.date.accessioned | 2019-09-02T11:56:35Z | |
dc.date.available | 2019-09-02T11:56:35Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0003-3197 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2765 | |
dc.description.abstract | Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA. | en |
dc.publisher | Sage Publications Inc, Thousand Oaks | |
dc.relation | Slovak Research and Development Agency of the Ministry of Education, Slovakia - VEGA 1/0863/15 | |
dc.rights | restrictedAccess | |
dc.source | Angiology | |
dc.title | Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Риззо, Манфреди; Ткацова, Рузена; Слаба, Ева; Стрбова, Зузана; Гојковић, Тамара; Куклисова, Зузана; Векић, Јелена; Јоппа, Павол; Хабалова, Виера; Тиско, Радован; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Побеха, Павол; | |
dc.citation.volume | 67 | |
dc.citation.issue | 10 | |
dc.citation.spage | 937 | |
dc.citation.epage | 944 | |
dc.citation.other | 67(10): 937-944 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000386036600009 | |
dc.identifier.doi | 10.1177/0003319716636512 | |
dc.identifier.pmid | 26941371 | |
dc.identifier.scopus | 2-s2.0-84990852858 | |
dc.type.version | publishedVersion |