Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)
Samo za registrovane korisnike
2017
Autori
Kolundžić, MarinaStanojković, Tatjana
Radović, Jelena
Tačić, Ana
Dodevska, Margarita
Milenković, Marina
Sisto, Francesca
Masia, Carla
Farronato, Giampietro
Nikolić, Vesna D.
Kundaković, Tatjana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/m...L. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.
Ključne reči:
antibacterial activity / ACE inhibitory activity / beta-glucan / Cantharellus cibarius / cytotoxicityIzvor:
Journal of Medicinal Food, 2017, 20, 8, 790-796Izdavač:
- Mary Ann Liebert, Inc, New Rochelle
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1089/jmf.2016.0176
ISSN: 1096-620X
PubMed: 28613963
WoS: 000407429600009
Scopus: 2-s2.0-85027382116
Institucija/grupa
PharmacyTY - JOUR AU - Kolundžić, Marina AU - Stanojković, Tatjana AU - Radović, Jelena AU - Tačić, Ana AU - Dodevska, Margarita AU - Milenković, Marina AU - Sisto, Francesca AU - Masia, Carla AU - Farronato, Giampietro AU - Nikolić, Vesna D. AU - Kundaković, Tatjana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2798 AB - Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds. PB - Mary Ann Liebert, Inc, New Rochelle T2 - Journal of Medicinal Food T1 - Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae) VL - 20 IS - 8 SP - 790 EP - 796 DO - 10.1089/jmf.2016.0176 ER -
@article{ author = "Kolundžić, Marina and Stanojković, Tatjana and Radović, Jelena and Tačić, Ana and Dodevska, Margarita and Milenković, Marina and Sisto, Francesca and Masia, Carla and Farronato, Giampietro and Nikolić, Vesna D. and Kundaković, Tatjana", year = "2017", abstract = "Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.", publisher = "Mary Ann Liebert, Inc, New Rochelle", journal = "Journal of Medicinal Food", title = "Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)", volume = "20", number = "8", pages = "790-796", doi = "10.1089/jmf.2016.0176" }
Kolundžić, M., Stanojković, T., Radović, J., Tačić, A., Dodevska, M., Milenković, M., Sisto, F., Masia, C., Farronato, G., Nikolić, V. D.,& Kundaković, T.. (2017). Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae). in Journal of Medicinal Food Mary Ann Liebert, Inc, New Rochelle., 20(8), 790-796. https://doi.org/10.1089/jmf.2016.0176
Kolundžić M, Stanojković T, Radović J, Tačić A, Dodevska M, Milenković M, Sisto F, Masia C, Farronato G, Nikolić VD, Kundaković T. Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae). in Journal of Medicinal Food. 2017;20(8):790-796. doi:10.1089/jmf.2016.0176 .
Kolundžić, Marina, Stanojković, Tatjana, Radović, Jelena, Tačić, Ana, Dodevska, Margarita, Milenković, Marina, Sisto, Francesca, Masia, Carla, Farronato, Giampietro, Nikolić, Vesna D., Kundaković, Tatjana, "Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)" in Journal of Medicinal Food, 20, no. 8 (2017):790-796, https://doi.org/10.1089/jmf.2016.0176 . .