Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
Апстракт
Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
Кључне речи:
Acetylsalicylic acid / CAS 103-90-2 / CAS 50-78-2 / Dissolution testing / Paracetamol / Tablets / experimental design / factorial designИзвор:
Pharmazeutische Industrie, 2001, 63, 7, 774-779Издавач:
- ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
Институција/група
PharmacyTY - JOUR AU - Parojčić, Jelena AU - Đurić, Zorica AU - Jovanović, M AU - Ibrić, Svetlana AU - Nikolić, L PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/284 AB - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape. PB - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf T2 - Pharmazeutische Industrie T1 - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design VL - 63 IS - 7 SP - 774 EP - 779 UR - https://hdl.handle.net/21.15107/rcub_farfar_284 ER -
@article{ author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L", year = "2001", abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.", publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf", journal = "Pharmazeutische Industrie", title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design", volume = "63", number = "7", pages = "774-779", url = "https://hdl.handle.net/21.15107/rcub_farfar_284" }
Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 63(7), 774-779. https://hdl.handle.net/21.15107/rcub_farfar_284
Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie. 2001;63(7):774-779. https://hdl.handle.net/21.15107/rcub_farfar_284 .
Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Pharmazeutische Industrie, 63, no. 7 (2001):774-779, https://hdl.handle.net/21.15107/rcub_farfar_284 .