Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients
2017
Autori
Miljković, MilicaStefanović, Aleksandra
Bogavac-Stanojević, Nataša
Simić-Ogrizović, Sanja
Dumić, Jerka
Cerne, Darko
Jelić-Ivanović, Zorana
Kotur-Stevuljević, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients w...ith high and low risk of a coronary event.
Ključne reči:
Kidney diseases / Pentraxin-3 / Galectin-3 / Matrix-metalloproteinase-9 / Tissue inhibitor of matrix metalloproteinase-1 / Risk factors / Risk assessment / Cardiovascular diseasesIzvor:
Acta Clinica Croatica, 2017, 56, 4, 673-680Izdavač:
- Sestre Milosrdnice Univ Hospital, Zagreb
Finansiranje / projekti:
DOI: 10.20471/acc.2017.56.04.14
ISSN: 0353-9466
PubMed: 29590722
WoS: 000426891900014
Scopus: 2-s2.0-85042388871
Institucija/grupa
PharmacyTY - JOUR AU - Miljković, Milica AU - Stefanović, Aleksandra AU - Bogavac-Stanojević, Nataša AU - Simić-Ogrizović, Sanja AU - Dumić, Jerka AU - Cerne, Darko AU - Jelić-Ivanović, Zorana AU - Kotur-Stevuljević, Jelena PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2886 AB - Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event. PB - Sestre Milosrdnice Univ Hospital, Zagreb T2 - Acta Clinica Croatica T1 - Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients VL - 56 IS - 4 SP - 673 EP - 680 DO - 10.20471/acc.2017.56.04.14 ER -
@article{ author = "Miljković, Milica and Stefanović, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Dumić, Jerka and Cerne, Darko and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena", year = "2017", abstract = "Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.", publisher = "Sestre Milosrdnice Univ Hospital, Zagreb", journal = "Acta Clinica Croatica", title = "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients", volume = "56", number = "4", pages = "673-680", doi = "10.20471/acc.2017.56.04.14" }
Miljković, M., Stefanović, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Dumić, J., Cerne, D., Jelić-Ivanović, Z.,& Kotur-Stevuljević, J.. (2017). Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica Sestre Milosrdnice Univ Hospital, Zagreb., 56(4), 673-680. https://doi.org/10.20471/acc.2017.56.04.14
Miljković M, Stefanović A, Bogavac-Stanojević N, Simić-Ogrizović S, Dumić J, Cerne D, Jelić-Ivanović Z, Kotur-Stevuljević J. Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica. 2017;56(4):673-680. doi:10.20471/acc.2017.56.04.14 .
Miljković, Milica, Stefanović, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Dumić, Jerka, Cerne, Darko, Jelić-Ivanović, Zorana, Kotur-Stevuljević, Jelena, "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients" in Acta Clinica Croatica, 56, no. 4 (2017):673-680, https://doi.org/10.20471/acc.2017.56.04.14 . .