Приказ основних података о документу
Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
dc.creator | Marinković, Valentina | |
dc.creator | Agbaba, Danica | |
dc.creator | Vladimirov, S | |
dc.creator | Stanković, S | |
dc.date.accessioned | 2019-09-02T10:53:26Z | |
dc.date.available | 2019-09-02T10:53:26Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/294 | |
dc.description.abstract | A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.title | Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Владимиров, С; Маринковић, Валентина; Aгбаба, Даница; Станковић, С; | |
dc.citation.volume | 24 | |
dc.citation.issue | 5-6 | |
dc.citation.spage | 993 | |
dc.citation.epage | 998 | |
dc.citation.other | 24(5-6): 993-998 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000167764200028 | |
dc.identifier.doi | 10.1016/S0731-7085(00)00531-8 | |
dc.identifier.pmid | 11248493 | |
dc.identifier.scopus | 2-s2.0-0035089540 | |
dc.type.version | publishedVersion |