Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data
Само за регистроване кориснике
2017
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay. Results: Cystatin C and anticardiolipin (aCL) antibodies of the immunoglobulin (Ig) G (r = .349, P = .004) and the IgM isotype (r = .316, P = .009) were in positive correlation. The IgG isotype of the aCL Abs was in positive correlation with creatinine (r = .252, P = .038), urea (r = .241, P = .048), and uric acid (r = .271, P = .025). The concentrations of the IgG isotype of the aCL Abs were significantly different between subgroups of patients with diabetic polyneuropathy and patients without this clinical f...inding (Mann-Whitney, P = .033). Conclusion: This is the first report on positive correlation between aCL Abs and renal impairment parameters. Larger studies are necessary for elucidation whether this association is involved in further progression of the disease.
Извор:
Clinical and Applied Thrombosis-Hemostasis, 2017, 23, 4, 379-383Издавач:
- Sage Publications Inc, Thousand Oaks
Финансирање / пројекти:
- Биомаркери оштећења и дисфункције органа (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.1177/1076029616642512
ISSN: 1076-0296
PubMed: 27056935
WoS: 000399751600010
Scopus: 2-s2.0-85018417848
Институција/група
PharmacyTY - JOUR AU - Becarević, Mirjana AU - Cabarkapa, Velibor AU - Derić, Mirjana AU - Ignjatović, Svetlana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3006 AB - Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay. Results: Cystatin C and anticardiolipin (aCL) antibodies of the immunoglobulin (Ig) G (r = .349, P = .004) and the IgM isotype (r = .316, P = .009) were in positive correlation. The IgG isotype of the aCL Abs was in positive correlation with creatinine (r = .252, P = .038), urea (r = .241, P = .048), and uric acid (r = .271, P = .025). The concentrations of the IgG isotype of the aCL Abs were significantly different between subgroups of patients with diabetic polyneuropathy and patients without this clinical finding (Mann-Whitney, P = .033). Conclusion: This is the first report on positive correlation between aCL Abs and renal impairment parameters. Larger studies are necessary for elucidation whether this association is involved in further progression of the disease. PB - Sage Publications Inc, Thousand Oaks T2 - Clinical and Applied Thrombosis-Hemostasis T1 - Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data VL - 23 IS - 4 SP - 379 EP - 383 DO - 10.1177/1076029616642512 ER -
@article{ author = "Becarević, Mirjana and Cabarkapa, Velibor and Derić, Mirjana and Ignjatović, Svetlana", year = "2017", abstract = "Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay. Results: Cystatin C and anticardiolipin (aCL) antibodies of the immunoglobulin (Ig) G (r = .349, P = .004) and the IgM isotype (r = .316, P = .009) were in positive correlation. The IgG isotype of the aCL Abs was in positive correlation with creatinine (r = .252, P = .038), urea (r = .241, P = .048), and uric acid (r = .271, P = .025). The concentrations of the IgG isotype of the aCL Abs were significantly different between subgroups of patients with diabetic polyneuropathy and patients without this clinical finding (Mann-Whitney, P = .033). Conclusion: This is the first report on positive correlation between aCL Abs and renal impairment parameters. Larger studies are necessary for elucidation whether this association is involved in further progression of the disease.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Clinical and Applied Thrombosis-Hemostasis", title = "Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data", volume = "23", number = "4", pages = "379-383", doi = "10.1177/1076029616642512" }
Becarević, M., Cabarkapa, V., Derić, M.,& Ignjatović, S.. (2017). Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data. in Clinical and Applied Thrombosis-Hemostasis Sage Publications Inc, Thousand Oaks., 23(4), 379-383. https://doi.org/10.1177/1076029616642512
Becarević M, Cabarkapa V, Derić M, Ignjatović S. Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data. in Clinical and Applied Thrombosis-Hemostasis. 2017;23(4):379-383. doi:10.1177/1076029616642512 .
Becarević, Mirjana, Cabarkapa, Velibor, Derić, Mirjana, Ignjatović, Svetlana, "Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data" in Clinical and Applied Thrombosis-Hemostasis, 23, no. 4 (2017):379-383, https://doi.org/10.1177/1076029616642512 . .