Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)
Само за регистроване кориснике
2017
Аутори
Suručić, Relja V.Kundaković, Tatjana
Lakušić, Branislava
Drakul, Dragana
Milovanović, Slobodan R.
Kovačević, Nada
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasi...i essential oil might have the potential therapeutic significance in hypertension.
Извор:
Chemistry & Biodiversity, 2017, 14, 5Издавач:
- Wiley-VCH Verlag GMBH, Weinheim
Финансирање / пројекти:
- Ministry of Science and Technology of Republic of Srpska - 19/6-020/961-110/14
DOI: 10.1002/cbdv.201600407
ISSN: 1612-1872
PubMed: 27943628
WoS: 000401239300004
Scopus: 2-s2.0-85017536066
Институција/група
PharmacyTY - JOUR AU - Suručić, Relja V. AU - Kundaković, Tatjana AU - Lakušić, Branislava AU - Drakul, Dragana AU - Milovanović, Slobodan R. AU - Kovačević, Nada PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3027 AB - The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension. PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Chemistry & Biodiversity T1 - Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae) VL - 14 IS - 5 DO - 10.1002/cbdv.201600407 ER -
@article{ author = "Suručić, Relja V. and Kundaković, Tatjana and Lakušić, Branislava and Drakul, Dragana and Milovanović, Slobodan R. and Kovačević, Nada", year = "2017", abstract = "The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Chemistry & Biodiversity", title = "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)", volume = "14", number = "5", doi = "10.1002/cbdv.201600407" }
Suručić, R. V., Kundaković, T., Lakušić, B., Drakul, D., Milovanović, S. R.,& Kovačević, N.. (2017). Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae). in Chemistry & Biodiversity Wiley-VCH Verlag GMBH, Weinheim., 14(5). https://doi.org/10.1002/cbdv.201600407
Suručić RV, Kundaković T, Lakušić B, Drakul D, Milovanović SR, Kovačević N. Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae). in Chemistry & Biodiversity. 2017;14(5). doi:10.1002/cbdv.201600407 .
Suručić, Relja V., Kundaković, Tatjana, Lakušić, Branislava, Drakul, Dragana, Milovanović, Slobodan R., Kovačević, Nada, "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)" in Chemistry & Biodiversity, 14, no. 5 (2017), https://doi.org/10.1002/cbdv.201600407 . .