The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
Samo za registrovane korisnike
2018
Autori
Klisić, AleksandraKotur-Stevuljević, Jelena
Kavarić, Nebojša
Martinović, Milica
Matić, Marija
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH leve...ls, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P lt 0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
Ključne reči:
Antioxidant defense / Follicle stimulating hormone / Obesity / Postmenopausal womenIzvor:
Eating and Weight Disorders, 2018, 23, 1, 133-141Izdavač:
- Springer, New York
Finansiranje / projekti:
DOI: 10.1007/s40519-016-0325-1
ISSN: 1124-4909
PubMed: 27663696
WoS: 000424649500015
Scopus: 2-s2.0-85047532417
Institucija/grupa
PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Kavarić, Nebojša AU - Martinović, Milica AU - Matić, Marija PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039 AB - Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P lt 0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship. PB - Springer, New York T2 - Eating and Weight Disorders T1 - The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women VL - 23 IS - 1 SP - 133 EP - 141 DO - 10.1007/s40519-016-0325-1 ER -
@article{ author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Martinović, Milica and Matić, Marija", year = "2018", abstract = "Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P lt 0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.", publisher = "Springer, New York", journal = "Eating and Weight Disorders", title = "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women", volume = "23", number = "1", pages = "133-141", doi = "10.1007/s40519-016-0325-1" }
Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Martinović, M.,& Matić, M.. (2018). The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders Springer, New York., 23(1), 133-141. https://doi.org/10.1007/s40519-016-0325-1
Klisić A, Kotur-Stevuljević J, Kavarić N, Martinović M, Matić M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders. 2018;23(1):133-141. doi:10.1007/s40519-016-0325-1 .
Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Martinović, Milica, Matić, Marija, "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women" in Eating and Weight Disorders, 23, no. 1 (2018):133-141, https://doi.org/10.1007/s40519-016-0325-1 . .