Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
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Ilić-Stojanović, SnežanaNikolić, Vesna D.
Kundaković, Tatjana
Savić, Ivan
Savić-Gajić, Ivana
Jocić, Emilija
Nikolić, Ljubiša
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Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl ass...ay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
Keywords:
Alchemilla vulgaris L / ellagic acid / hydrogels / N-isopropylacrylamide / thermosensitive releaseSource:
International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, 67, 9, 553-563Publisher:
- Taylor & Francis As, Oslo
Funding / projects:
- Plants and synthetic bioactive products of new generation (RS-MESTD-Technological Development (TD or TR)-34012)
Note:
- Peer-reviewed manuscript: http://farfar.pharmacy.bg.ac.rs/handle/123456789/3421
DOI: 10.1080/00914037.2017.1354202
ISSN: 0091-4037
WoS: 000429604500003
Scopus: 2-s2.0-85029429225
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PharmacyTY - JOUR AU - Ilić-Stojanović, Snežana AU - Nikolić, Vesna D. AU - Kundaković, Tatjana AU - Savić, Ivan AU - Savić-Gajić, Ivana AU - Jocić, Emilija AU - Nikolić, Ljubiša PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3155 AB - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS] PB - Taylor & Francis As, Oslo T2 - International Journal of Polymeric Materials and Polymeric Biomaterials T1 - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract VL - 67 IS - 9 SP - 553 EP - 563 DO - 10.1080/00914037.2017.1354202 ER -
@article{ author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša", year = "2018", abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]", publisher = "Taylor & Francis As, Oslo", journal = "International Journal of Polymeric Materials and Polymeric Biomaterials", title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract", volume = "67", number = "9", pages = "553-563", doi = "10.1080/00914037.2017.1354202" }
Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials Taylor & Francis As, Oslo., 67(9), 553-563. https://doi.org/10.1080/00914037.2017.1354202
Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563. doi:10.1080/00914037.2017.1354202 .
Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563, https://doi.org/10.1080/00914037.2017.1354202 . .