Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?
Само за регистроване кориснике
2018
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating... Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.
Кључне речи:
lipid accumulation product / obesity / type 2 diabetes mellitus / visceral adiposity indexИзвор:
Journal of Clinical Laboratory Analysis, 2018, 32, 3Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
DOI: 10.1002/jcla.22283
ISSN: 0887-8013
PubMed: 28632304
WoS: 000427567700008
Scopus: 2-s2.0-85021276172
Институција/група
PharmacyTY - JOUR AU - Kavarić, Nebojša AU - Klisić, Aleksandra AU - Ninić, Ana PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3175 AB - BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction. PB - Wiley, Hoboken T2 - Journal of Clinical Laboratory Analysis T1 - Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus? VL - 32 IS - 3 DO - 10.1002/jcla.22283 ER -
@article{ author = "Kavarić, Nebojša and Klisić, Aleksandra and Ninić, Ana", year = "2018", abstract = "BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.", publisher = "Wiley, Hoboken", journal = "Journal of Clinical Laboratory Analysis", title = "Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?", volume = "32", number = "3", doi = "10.1002/jcla.22283" }
Kavarić, N., Klisić, A.,& Ninić, A.. (2018). Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?. in Journal of Clinical Laboratory Analysis Wiley, Hoboken., 32(3). https://doi.org/10.1002/jcla.22283
Kavarić N, Klisić A, Ninić A. Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?. in Journal of Clinical Laboratory Analysis. 2018;32(3). doi:10.1002/jcla.22283 .
Kavarić, Nebojša, Klisić, Aleksandra, Ninić, Ana, "Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?" in Journal of Clinical Laboratory Analysis, 32, no. 3 (2018), https://doi.org/10.1002/jcla.22283 . .