Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives
Само за регистроване кориснике
2018
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underline...d.
Кључне речи:
Reversed-phased thin-layer chromatography / 17 beta-Carboxamide glucocorticoid derivatives / log Po/w / Simple linear regressionИзвор:
Journal of Planar Chromatography - Modern TLC, 2018, 31, 3, 250-256Издавач:
- Akademiai Kiado Zrt, Budapest
Финансирање / пројекти:
- Развој молекула са антиинфламаторним и кардиопроактивним дејством: структурне модификације, моделовање, физичкохемијска карактеризација и формулациона испитивања (RS-MESTD-Basic Research (BR or ON)-172041)
DOI: 10.1556/1006.2018.31.3.11
ISSN: 0933-4173
WoS: 000439814400012
Scopus: 2-s2.0-85048951338
Институција/група
PharmacyTY - JOUR AU - Dobričić, Vladimir AU - Stanišić, Aleksa AU - Vladimirov, Sote AU - Čudina, Olivera PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3209 AB - Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underlined. PB - Akademiai Kiado Zrt, Budapest T2 - Journal of Planar Chromatography - Modern TLC T1 - Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives VL - 31 IS - 3 SP - 250 EP - 256 DO - 10.1556/1006.2018.31.3.11 ER -
@article{ author = "Dobričić, Vladimir and Stanišić, Aleksa and Vladimirov, Sote and Čudina, Olivera", year = "2018", abstract = "Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underlined.", publisher = "Akademiai Kiado Zrt, Budapest", journal = "Journal of Planar Chromatography - Modern TLC", title = "Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives", volume = "31", number = "3", pages = "250-256", doi = "10.1556/1006.2018.31.3.11" }
Dobričić, V., Stanišić, A., Vladimirov, S.,& Čudina, O.. (2018). Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives. in Journal of Planar Chromatography - Modern TLC Akademiai Kiado Zrt, Budapest., 31(3), 250-256. https://doi.org/10.1556/1006.2018.31.3.11
Dobričić V, Stanišić A, Vladimirov S, Čudina O. Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives. in Journal of Planar Chromatography - Modern TLC. 2018;31(3):250-256. doi:10.1556/1006.2018.31.3.11 .
Dobričić, Vladimir, Stanišić, Aleksa, Vladimirov, Sote, Čudina, Olivera, "Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives" in Journal of Planar Chromatography - Modern TLC, 31, no. 3 (2018):250-256, https://doi.org/10.1556/1006.2018.31.3.11 . .