Opioids and adjuvant analgesics in current treating of pain
Opioidni i adjuvantni analgetici u savremenom lečenju bola
Abstract
Morphine, as a paradigm of opioids, is 'gold standard' in treating severe pain, to which all other drugs are compared. However, abuse and respiratory depression potentials have resulted in 'opiophobia' among health professionals, and underutilization of opioids as analgesics. But, addiction and respiratory depression are almost never present in pain managenent in palliative care. So, fear of addiction and respiratory depression should not prevent increasing of opioid dose in those patients in paliative care who still suffer of severe pain. Opioids are ineffective in treating neuropathic pain. Antiepileptics (carbamazepine, pregabalin, gabapentin) and antidepressants (amitriptyline, duloxetine) are used for neuropathic pain.
Morfin, kao primer opioida se smatra 'zlatnim standardom' u lečenju jakih bolova, sa kojim se svi drugi lekovi porede. Međutim, potencijal opioida da izazovu zavisnost/adikciju i depresiju disanja stvorilo je tzv. 'opiofobe' među zdravstvenim radnicima, zbog kojih se opioidi nedovoljno koriste u lečenju jakih bolova. Ali, adikcija i izrazita depresija disanja gotovo nikada ne mogu da se jave u terminalnih pacijenata. Zato strah od zavisnosti i respiratorne depresije ne treba da spreči povećanje doze opioida kada pacijent i dalje pati od bola. Opioidi su slabo efikasni u lečenju neuropatskih bolova. Za lečenje neuropatskih bolova koriste se antiepileptici (karbamazepin, pregabalin, gabapentin) i antidepresivi (amitriptilin, duloksetin).
Keywords:
morphine / opioids / tolerance / dependence / neuropathic pain / morfin / opioidi / tolerancija / zavisnost / adjuvantni analgeticiSource:
Arhiv za farmaciju, 2019, 69, 1, 1009-1020Publisher:
- Savez farmaceutskih udruženja Srbije, Beograd
Funding / projects:
- Examination of mechanisms of action, toxicity and interactions of adjuvant analgesics (RS-MESTD-Basic Research (BR or ON)-175045)
Collections
Institution/Community
PharmacyTY - JOUR AU - Stepanović-Petrović, Radica AU - Tomić, Maja PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3284 AB - Morphine, as a paradigm of opioids, is 'gold standard' in treating severe pain, to which all other drugs are compared. However, abuse and respiratory depression potentials have resulted in 'opiophobia' among health professionals, and underutilization of opioids as analgesics. But, addiction and respiratory depression are almost never present in pain managenent in palliative care. So, fear of addiction and respiratory depression should not prevent increasing of opioid dose in those patients in paliative care who still suffer of severe pain. Opioids are ineffective in treating neuropathic pain. Antiepileptics (carbamazepine, pregabalin, gabapentin) and antidepressants (amitriptyline, duloxetine) are used for neuropathic pain. AB - Morfin, kao primer opioida se smatra 'zlatnim standardom' u lečenju jakih bolova, sa kojim se svi drugi lekovi porede. Međutim, potencijal opioida da izazovu zavisnost/adikciju i depresiju disanja stvorilo je tzv. 'opiofobe' među zdravstvenim radnicima, zbog kojih se opioidi nedovoljno koriste u lečenju jakih bolova. Ali, adikcija i izrazita depresija disanja gotovo nikada ne mogu da se jave u terminalnih pacijenata. Zato strah od zavisnosti i respiratorne depresije ne treba da spreči povećanje doze opioida kada pacijent i dalje pati od bola. Opioidi su slabo efikasni u lečenju neuropatskih bolova. Za lečenje neuropatskih bolova koriste se antiepileptici (karbamazepin, pregabalin, gabapentin) i antidepresivi (amitriptilin, duloksetin). PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - Opioids and adjuvant analgesics in current treating of pain T1 - Opioidni i adjuvantni analgetici u savremenom lečenju bola VL - 69 IS - 1 SP - 1009 EP - 1020 DO - 10.5937/ArhFarm1901009S ER -
@article{ author = "Stepanović-Petrović, Radica and Tomić, Maja", year = "2019", abstract = "Morphine, as a paradigm of opioids, is 'gold standard' in treating severe pain, to which all other drugs are compared. However, abuse and respiratory depression potentials have resulted in 'opiophobia' among health professionals, and underutilization of opioids as analgesics. But, addiction and respiratory depression are almost never present in pain managenent in palliative care. So, fear of addiction and respiratory depression should not prevent increasing of opioid dose in those patients in paliative care who still suffer of severe pain. Opioids are ineffective in treating neuropathic pain. Antiepileptics (carbamazepine, pregabalin, gabapentin) and antidepressants (amitriptyline, duloxetine) are used for neuropathic pain., Morfin, kao primer opioida se smatra 'zlatnim standardom' u lečenju jakih bolova, sa kojim se svi drugi lekovi porede. Međutim, potencijal opioida da izazovu zavisnost/adikciju i depresiju disanja stvorilo je tzv. 'opiofobe' među zdravstvenim radnicima, zbog kojih se opioidi nedovoljno koriste u lečenju jakih bolova. Ali, adikcija i izrazita depresija disanja gotovo nikada ne mogu da se jave u terminalnih pacijenata. Zato strah od zavisnosti i respiratorne depresije ne treba da spreči povećanje doze opioida kada pacijent i dalje pati od bola. Opioidi su slabo efikasni u lečenju neuropatskih bolova. Za lečenje neuropatskih bolova koriste se antiepileptici (karbamazepin, pregabalin, gabapentin) i antidepresivi (amitriptilin, duloksetin).", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Opioids and adjuvant analgesics in current treating of pain, Opioidni i adjuvantni analgetici u savremenom lečenju bola", volume = "69", number = "1", pages = "1009-1020", doi = "10.5937/ArhFarm1901009S" }
Stepanović-Petrović, R.,& Tomić, M.. (2019). Opioids and adjuvant analgesics in current treating of pain. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 69(1), 1009-1020. https://doi.org/10.5937/ArhFarm1901009S
Stepanović-Petrović R, Tomić M. Opioids and adjuvant analgesics in current treating of pain. in Arhiv za farmaciju. 2019;69(1):1009-1020. doi:10.5937/ArhFarm1901009S .
Stepanović-Petrović, Radica, Tomić, Maja, "Opioids and adjuvant analgesics in current treating of pain" in Arhiv za farmaciju, 69, no. 1 (2019):1009-1020, https://doi.org/10.5937/ArhFarm1901009S . .