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Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity
dc.creator | Nikolić, Ines | |
dc.creator | Mitsou, Evgenia | |
dc.creator | Damjanović, Ana | |
dc.creator | Papadimitriou, Vassiliki | |
dc.creator | Antić-Stanković, Jelena | |
dc.creator | Stanojević, Boban | |
dc.creator | Xenakis, Aristotelis | |
dc.creator | Savić, Snežana | |
dc.date.accessioned | 2020-02-21T10:45:36Z | |
dc.date.available | 2020-02-21T10:45:36Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0167-7322 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3528 | |
dc.description.abstract | The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI < 0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities. | en |
dc.publisher | Elsevier B.V. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.relation | Development of Micro- and Nanosystems as Carriers for Drugswith Anti-inflammatory Effect and Methods for Their Characterizationand OI 175011 Biological response modifiers in physiological and path-ological conditions. | |
dc.rights | restrictedAccess | |
dc.source | Journal of Molecular Liquids | |
dc.subject | Low-energy nanoemulsions | |
dc.subject | Spontaneous emulsification | |
dc.subject | Curcumin | |
dc.subject | Atomic force microscopy | |
dc.subject | Antioxidant activity | |
dc.subject | (Anti)genotoxicity | |
dc.title | Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станојевић, Бобан; Xенакис, Aристотелис; Дамјановић, Aна; Николић, Инес; Митсоу, Евгениа; Пападимитриоу, Вассилики; Савић, Снежана; Aнтић-Станковић, Јелена; | |
dc.citation.volume | 301 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000517659700090 | |
dc.identifier.doi | 10.1016/j.molliq.2020.112479 | |
dc.identifier.scopus | 2-s2.0-85078037387 | |
dc.type.version | publishedVersion |