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Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy
dc.creator | Micov, Ana | |
dc.creator | Tomić, Maja | |
dc.creator | Todorović, Marija B. | |
dc.creator | Vuković, Milja | |
dc.creator | Pecikoza, Uroš | |
dc.creator | Jasnić, Nebojša | |
dc.creator | Đorđević, Jelena D. | |
dc.creator | Stepanović-Petrović, Radica | |
dc.date.accessioned | 2020-06-10T07:03:15Z | |
dc.date.available | 2020-06-10T07:03:15Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0278-5846 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3600 | |
dc.description.abstract | Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatment of symptoms of neuropathy and concomitant depression. We examined the effects of vortioxetine, a novel antidepressant with unique mechanism of action, on pain hypersensitivity and depression-like behavior in oxaliplatin-induced neuropathy model in mice (OIPN). Vortioxetine (1–10 mg/kg, p.o.) significantly and dose-dependently reduced mechanical allodynia in von Frey test and cold allodynia in acetone test in OIPN mice, in both repeated prophylactic and acute therapeutic treatment regimens. It also reduced depression-like behavior in the forced swimming test in OIPN mice, in both treatment paradigms. Its antiallodynic and antidepressive-like effects were comparable to those exerted by duloxetine (1–15 mg/kg, p.o.). The antiallodynic and antidepressive-like effects of repeatedly administered vortioxetine might be related to the increased content of 5-hydroxytryptamine (5- HT) and noradrenaline (NA), detected in the brainstem of treated OIPN mice. These results indicate that vortioxetine could be potentially useful in prevention and treatment of chemotherapy-induced neuropathy, for the relief of pain and concomitant depressive symptoms. It should be further tested to this regard in clinical settings. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS// | |
dc.rights | restrictedAccess | |
dc.source | Progress in Neuro-Psychopharmacology and Biological Psychiatry | |
dc.subject | Brainstem 5-HT and NA content | |
dc.subject | Depression-like behavior | |
dc.subject | Mechanical/cold allodynia | |
dc.subject | Oxaliplatin-induced neuropathy | |
dc.subject | Vortioxetine | |
dc.title | Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђорђевић, Јелена Д.; Тодоровић, Марија Б.; Јаснић, Небојша; Мицов, Aна; Томић, Маја; Вуковић, Миља; Пецикоза, Урош; Степановић-Петровић, Радица; | |
dc.citation.volume | 103 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000541704700010 | |
dc.identifier.doi | 10.1016/j.pnpbp.2020.109975 | |
dc.identifier.scopus | 2-s2.0-85085640492 | |
dc.type.version | publishedVersion |