Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery
Abstract
The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
Source:
Archives of Physiology and Biochemistry, 1988, 96, 3, 197-200Publisher:
- Informa Healthcare
Note:
- Union of the Scientific Medical Institutions of Serbia (Grant No. 231).
Collections
Institution/Community
PharmacyTY - JOUR AU - Krstić, M.K AU - Stepanović-Petrović, Radica AU - Krstić, S.K AU - Katušić, Z.S PY - 1988 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/39 AB - The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors. PB - Informa Healthcare T2 - Archives of Physiology and Biochemistry T1 - Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery VL - 96 IS - 3 SP - 197 EP - 200 DO - 10.3109/13813458809075944 ER -
@article{ author = "Krstić, M.K and Stepanović-Petrović, Radica and Krstić, S.K and Katušić, Z.S", year = "1988", abstract = "The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.", publisher = "Informa Healthcare", journal = "Archives of Physiology and Biochemistry", title = "Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery", volume = "96", number = "3", pages = "197-200", doi = "10.3109/13813458809075944" }
Krstić, M.K, Stepanović-Petrović, R., Krstić, S.K,& Katušić, Z.S. (1988). Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery. in Archives of Physiology and Biochemistry Informa Healthcare., 96(3), 197-200. https://doi.org/10.3109/13813458809075944
Krstić M, Stepanović-Petrović R, Krstić S, Katušić Z. Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery. in Archives of Physiology and Biochemistry. 1988;96(3):197-200. doi:10.3109/13813458809075944 .
Krstić, M.K, Stepanović-Petrović, Radica, Krstić, S.K, Katušić, Z.S, "Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery" in Archives of Physiology and Biochemistry, 96, no. 3 (1988):197-200, https://doi.org/10.3109/13813458809075944 . .