Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery
Samo za registrovane korisnike
1988
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
Izvor:
Archives of Physiology and Biochemistry, 1988, 96, 3, 197-200Izdavač:
- Informa Healthcare
Napomena:
- Union of the Scientific Medical Institutions of Serbia (Grant No. 231).
Institucija/grupa
PharmacyTY - JOUR AU - Krstić, M.K AU - Stepanović-Petrović, Radica AU - Krstić, S.K AU - Katušić, Z.S PY - 1988 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/39 AB - The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors. PB - Informa Healthcare T2 - Archives of Physiology and Biochemistry T1 - Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery VL - 96 IS - 3 SP - 197 EP - 200 DO - 10.3109/13813458809075944 ER -
@article{ author = "Krstić, M.K and Stepanović-Petrović, Radica and Krstić, S.K and Katušić, Z.S", year = "1988", abstract = "The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.", publisher = "Informa Healthcare", journal = "Archives of Physiology and Biochemistry", title = "Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery", volume = "96", number = "3", pages = "197-200", doi = "10.3109/13813458809075944" }
Krstić, M.K, Stepanović-Petrović, R., Krstić, S.K,& Katušić, Z.S. (1988). Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery. in Archives of Physiology and Biochemistry Informa Healthcare., 96(3), 197-200. https://doi.org/10.3109/13813458809075944
Krstić M, Stepanović-Petrović R, Krstić S, Katušić Z. Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery. in Archives of Physiology and Biochemistry. 1988;96(3):197-200. doi:10.3109/13813458809075944 .
Krstić, M.K, Stepanović-Petrović, Radica, Krstić, S.K, Katušić, Z.S, "Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery" in Archives of Physiology and Biochemistry, 96, no. 3 (1988):197-200, https://doi.org/10.3109/13813458809075944 . .