Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening
Само за регистроване кориснике
2022
Аутори
Živančević, KatarinaBaralić, Katarina
Božić, Dragica
Antonijević-Miljaković, Evica
Buha-Đorđević, Aleksandra
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Bulat, Petar
Đukić-Ćosić, Danijela
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organizat...ion and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.
Кључне речи:
Toxicogenomic data mining / Alzheimer's diesase / Berberine / Environmentally relevant toxic metal mixture / Molecular mechanismsИзвор:
Food and Chemical Toxicology, 2022, 161Издавач:
- Elsevier Ltd
Финансирање / пројекти:
DOI: 10.1016/j.fct.2022.112839
ISSN: 0278-6915
WoS: 000750832500001
Scopus: 2-s2.0-85123701707
Институција/група
PharmacyTY - JOUR AU - Živančević, Katarina AU - Baralić, Katarina AU - Božić, Dragica AU - Antonijević-Miljaković, Evica AU - Buha-Đorđević, Aleksandra AU - Ćurčić, Marijana AU - Bulat, Zorica AU - Antonijević, Biljana AU - Bulat, Petar AU - Đukić-Ćosić, Danijela PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4052 AB - We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier. PB - Elsevier Ltd T2 - Food and Chemical Toxicology T1 - Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening VL - 161 DO - 10.1016/j.fct.2022.112839 ER -
@article{ author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Bulat, Petar and Đukić-Ćosić, Danijela", year = "2022", abstract = "We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.", publisher = "Elsevier Ltd", journal = "Food and Chemical Toxicology", title = "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening", volume = "161", doi = "10.1016/j.fct.2022.112839" }
Živančević, K., Baralić, K., Božić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B., Bulat, P.,& Đukić-Ćosić, D.. (2022). Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology Elsevier Ltd., 161. https://doi.org/10.1016/j.fct.2022.112839
Živančević K, Baralić K, Božić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Bulat P, Đukić-Ćosić D. Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology. 2022;161. doi:10.1016/j.fct.2022.112839 .
Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Bulat, Petar, Đukić-Ćosić, Danijela, "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening" in Food and Chemical Toxicology, 161 (2022), https://doi.org/10.1016/j.fct.2022.112839 . .