Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts
Аутори
Pizent, AlicaAnđelković, Milena
Tariba Lovaković, Blanka
Živković Semren, Tanja
Buha-Đorđević, Aleksandra
Gamulin, Marija
Bonderović, Vera
Aćimović, Miodrag
Bulat, Zorica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant ...inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.
Кључне речи:
oxidative stress / antioxidant enzymes / prostate cancer / PSA / toxic metal(loid)sИзвор:
Antioxidants, 2022, 11, 10Издавач:
- MDPI
Финансирање / пројекти:
- The Ministry of Science, Education, and Sports of the Republic of Croatia (project No. 022-0222411-2408)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/antiox11102044
ISSN: 2076-3921
WoS: 000872087200001
Scopus: 2-s2.0-85140469889
Институција/група
PharmacyTY - JOUR AU - Pizent, Alica AU - Anđelković, Milena AU - Tariba Lovaković, Blanka AU - Živković Semren, Tanja AU - Buha-Đorđević, Aleksandra AU - Gamulin, Marija AU - Bonderović, Vera AU - Aćimović, Miodrag AU - Bulat, Zorica PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4301 AB - We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results. PB - MDPI T2 - Antioxidants T1 - Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts VL - 11 IS - 10 DO - 10.3390/antiox11102044 ER -
@article{ author = "Pizent, Alica and Anđelković, Milena and Tariba Lovaković, Blanka and Živković Semren, Tanja and Buha-Đorđević, Aleksandra and Gamulin, Marija and Bonderović, Vera and Aćimović, Miodrag and Bulat, Zorica", year = "2022", abstract = "We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.", publisher = "MDPI", journal = "Antioxidants", title = "Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts", volume = "11", number = "10", doi = "10.3390/antiox11102044" }
Pizent, A., Anđelković, M., Tariba Lovaković, B., Živković Semren, T., Buha-Đorđević, A., Gamulin, M., Bonderović, V., Aćimović, M.,& Bulat, Z.. (2022). Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts. in Antioxidants MDPI., 11(10). https://doi.org/10.3390/antiox11102044
Pizent A, Anđelković M, Tariba Lovaković B, Živković Semren T, Buha-Đorđević A, Gamulin M, Bonderović V, Aćimović M, Bulat Z. Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts. in Antioxidants. 2022;11(10). doi:10.3390/antiox11102044 .
Pizent, Alica, Anđelković, Milena, Tariba Lovaković, Blanka, Živković Semren, Tanja, Buha-Đorđević, Aleksandra, Gamulin, Marija, Bonderović, Vera, Aćimović, Miodrag, Bulat, Zorica, "Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts" in Antioxidants, 11, no. 10 (2022), https://doi.org/10.3390/antiox11102044 . .