Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
Аутори
Vujčić, SanjaKotur-Stevuljević, Jelena
Vekić, Jelena
Perović-Blagojević, Iva
Stefanović, Tatjana
Ilić-Mijailović, Sanja
Koprivica Uzelac, Branka
Bosić, Srećko
Antonić, Tamara
Guzonjić, Azra
Mastilović, Ana-Marija
Marković, Zorica
Rizzo, Manfredi
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF ...group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development.
Кључне речи:
oxidative stress / diabetes mellitus / diabetic foot / NLR / PABИзвор:
Medicina (Lithuania), 2022, 58, 12Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/medicina58121866
ISSN: 1010-660X
WoS: 000902834300001
Scopus: 2-s2.0-85144545308
Институција/група
PharmacyTY - JOUR AU - Vujčić, Sanja AU - Kotur-Stevuljević, Jelena AU - Vekić, Jelena AU - Perović-Blagojević, Iva AU - Stefanović, Tatjana AU - Ilić-Mijailović, Sanja AU - Koprivica Uzelac, Branka AU - Bosić, Srećko AU - Antonić, Tamara AU - Guzonjić, Azra AU - Mastilović, Ana-Marija AU - Marković, Zorica AU - Rizzo, Manfredi PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4369 AB - Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development. PB - MDPI T2 - Medicina (Lithuania) T1 - Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot VL - 58 IS - 12 DO - 10.3390/medicina58121866 ER -
@article{ author = "Vujčić, Sanja and Kotur-Stevuljević, Jelena and Vekić, Jelena and Perović-Blagojević, Iva and Stefanović, Tatjana and Ilić-Mijailović, Sanja and Koprivica Uzelac, Branka and Bosić, Srećko and Antonić, Tamara and Guzonjić, Azra and Mastilović, Ana-Marija and Marković, Zorica and Rizzo, Manfredi", year = "2022", abstract = "Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development.", publisher = "MDPI", journal = "Medicina (Lithuania)", title = "Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot", volume = "58", number = "12", doi = "10.3390/medicina58121866" }
Vujčić, S., Kotur-Stevuljević, J., Vekić, J., Perović-Blagojević, I., Stefanović, T., Ilić-Mijailović, S., Koprivica Uzelac, B., Bosić, S., Antonić, T., Guzonjić, A., Mastilović, A., Marković, Z.,& Rizzo, M.. (2022). Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot. in Medicina (Lithuania) MDPI., 58(12). https://doi.org/10.3390/medicina58121866
Vujčić S, Kotur-Stevuljević J, Vekić J, Perović-Blagojević I, Stefanović T, Ilić-Mijailović S, Koprivica Uzelac B, Bosić S, Antonić T, Guzonjić A, Mastilović A, Marković Z, Rizzo M. Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot. in Medicina (Lithuania). 2022;58(12). doi:10.3390/medicina58121866 .
Vujčić, Sanja, Kotur-Stevuljević, Jelena, Vekić, Jelena, Perović-Blagojević, Iva, Stefanović, Tatjana, Ilić-Mijailović, Sanja, Koprivica Uzelac, Branka, Bosić, Srećko, Antonić, Tamara, Guzonjić, Azra, Mastilović, Ana-Marija, Marković, Zorica, Rizzo, Manfredi, "Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot" in Medicina (Lithuania), 58, no. 12 (2022), https://doi.org/10.3390/medicina58121866 . .