Exposure to mercury and thyroid function: Is there a connection?
Izloženost živi i funkcija štitaste žlezde: postoji li veza?
Аутори
Marić, ĐurđicaBonderović, Vera
Javorac, Dragana
Baralić, Katarina
Bulat, Zorica
Đukić-Ćosić, Danijela
Mandić-Rajčević, Stefan
Žarković, Miloš
Buha-Đorđević, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mercury (Hg) is one of the most important environmental pollutants with endocrine-
disrupting properties. There is little data from epidemiological studies describing the dose-
response relationship between toxic metal levels and hormone levels. The aim of this study was
to use the nearest neighbor matching analysis to determine the difference in Hg concentration in
healthy/sick subjects with thyroid disease and to use Benchmark modeling to determine the dose-
response relationship between Hg levels in the blood and thyroid-stimulating hormone (TSH) and
thyroid hormones in serum. Blood samples were collected and used for Hg measurement using
the ICP-MS method, and separated serum was used for hormone analysis. The study showed the
existence of a statistically significant difference in Hg levels measured in healthy and sick subjects
and the existence of a dose-response relationship between Hg and all measured hormones, with a
narrow interval obtained for the Hg-TSH pair. The r...esults of this research support the use of the
Benchmark dose approach for the purpose of analyzing data from human studies, and our further
research will be focused on examining the impact of low doses on animal models in order to
determine more precise effects of low doses on the organism.
Živa (Hg) je jedan od najznačajnijih zagađivača životne sredine sa osobinama endokrinog ometača. Malo je podataka iz epidemioloških studija koji opisuju odnos doza-odgovor između nivoa toksičnih metala i nivoa hormona. Cilj ovog rada bio je da primenom nearest neighbor matching analize utvrdi razliku u koncentraciji Hg kod zdravih/obolelih ispitanika od bolesti štitaste žlezde i da primenom Benchmark modelovanja utvrdi odnos doza-odgovor između nivoa Hg u krvi i tireostimulišućeg hormona (TSH) i tiroidnih hormona u serumu. Uzorci krvi su sakupljeni i korišćeni za merenje Hg uz pomoć ICP-MS metode, a izdvojeni serum korišćen je za analizu hormona. Studija je pokazala postojanje statistički značajne razlike u nivoima Hg koji su izmereni kod zdravih i bolesnih ispitanika i postojanje odnosa doza-odgovor između Hg i svih merenih hormona, pri čemu je uzak interval dobijen za Hg-TSH par. Rezultati ovog istraživanja podržavaju upotrebu Benchmark dose pristupa u svrhu analize podataka iz human...ih studija, a naša dalja istraživanja će biti usmerena na ispitivanje uticaja niskih doza na životinjskim modelima, u cilju utvrđivanja preciznijih efekata niskih doza na organizam.
Кључне речи:
endocrine disruption / mercury / thyroid function / BMD concept / nearest neighbor matching / endokrini ometači / živa / funkcija štitaste žlezde / BMD konceptИзвор:
Arhiv za farmaciju, 2022, 72, 5, 468-485Издавач:
- Beograd : Savez farmaceutskih udruženja Srbije
Финансирање / пројекти:
- DecodExpo - Decoding the Role of Exposome in Endocrine Health (RS-ScienceFundRS-Promis-6066532)
Институција/група
PharmacyTY - JOUR AU - Marić, Đurđica AU - Bonderović, Vera AU - Javorac, Dragana AU - Baralić, Katarina AU - Bulat, Zorica AU - Đukić-Ćosić, Danijela AU - Mandić-Rajčević, Stefan AU - Žarković, Miloš AU - Buha-Đorđević, Aleksandra PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4400 AB - Mercury (Hg) is one of the most important environmental pollutants with endocrine- disrupting properties. There is little data from epidemiological studies describing the dose- response relationship between toxic metal levels and hormone levels. The aim of this study was to use the nearest neighbor matching analysis to determine the difference in Hg concentration in healthy/sick subjects with thyroid disease and to use Benchmark modeling to determine the dose- response relationship between Hg levels in the blood and thyroid-stimulating hormone (TSH) and thyroid hormones in serum. Blood samples were collected and used for Hg measurement using the ICP-MS method, and separated serum was used for hormone analysis. The study showed the existence of a statistically significant difference in Hg levels measured in healthy and sick subjects and the existence of a dose-response relationship between Hg and all measured hormones, with a narrow interval obtained for the Hg-TSH pair. The results of this research support the use of the Benchmark dose approach for the purpose of analyzing data from human studies, and our further research will be focused on examining the impact of low doses on animal models in order to determine more precise effects of low doses on the organism. AB - Živa (Hg) je jedan od najznačajnijih zagađivača životne sredine sa osobinama endokrinog ometača. Malo je podataka iz epidemioloških studija koji opisuju odnos doza-odgovor između nivoa toksičnih metala i nivoa hormona. Cilj ovog rada bio je da primenom nearest neighbor matching analize utvrdi razliku u koncentraciji Hg kod zdravih/obolelih ispitanika od bolesti štitaste žlezde i da primenom Benchmark modelovanja utvrdi odnos doza-odgovor između nivoa Hg u krvi i tireostimulišućeg hormona (TSH) i tiroidnih hormona u serumu. Uzorci krvi su sakupljeni i korišćeni za merenje Hg uz pomoć ICP-MS metode, a izdvojeni serum korišćen je za analizu hormona. Studija je pokazala postojanje statistički značajne razlike u nivoima Hg koji su izmereni kod zdravih i bolesnih ispitanika i postojanje odnosa doza-odgovor između Hg i svih merenih hormona, pri čemu je uzak interval dobijen za Hg-TSH par. Rezultati ovog istraživanja podržavaju upotrebu Benchmark dose pristupa u svrhu analize podataka iz humanih studija, a naša dalja istraživanja će biti usmerena na ispitivanje uticaja niskih doza na životinjskim modelima, u cilju utvrđivanja preciznijih efekata niskih doza na organizam. PB - Beograd : Savez farmaceutskih udruženja Srbije T2 - Arhiv za farmaciju T1 - Exposure to mercury and thyroid function: Is there a connection? T1 - Izloženost živi i funkcija štitaste žlezde: postoji li veza? VL - 72 IS - 5 SP - 468 EP - 485 DO - 10.5937/arhfarm72-40122 ER -
@article{ author = "Marić, Đurđica and Bonderović, Vera and Javorac, Dragana and Baralić, Katarina and Bulat, Zorica and Đukić-Ćosić, Danijela and Mandić-Rajčević, Stefan and Žarković, Miloš and Buha-Đorđević, Aleksandra", year = "2022", abstract = "Mercury (Hg) is one of the most important environmental pollutants with endocrine- disrupting properties. There is little data from epidemiological studies describing the dose- response relationship between toxic metal levels and hormone levels. The aim of this study was to use the nearest neighbor matching analysis to determine the difference in Hg concentration in healthy/sick subjects with thyroid disease and to use Benchmark modeling to determine the dose- response relationship between Hg levels in the blood and thyroid-stimulating hormone (TSH) and thyroid hormones in serum. Blood samples were collected and used for Hg measurement using the ICP-MS method, and separated serum was used for hormone analysis. The study showed the existence of a statistically significant difference in Hg levels measured in healthy and sick subjects and the existence of a dose-response relationship between Hg and all measured hormones, with a narrow interval obtained for the Hg-TSH pair. The results of this research support the use of the Benchmark dose approach for the purpose of analyzing data from human studies, and our further research will be focused on examining the impact of low doses on animal models in order to determine more precise effects of low doses on the organism., Živa (Hg) je jedan od najznačajnijih zagađivača životne sredine sa osobinama endokrinog ometača. Malo je podataka iz epidemioloških studija koji opisuju odnos doza-odgovor između nivoa toksičnih metala i nivoa hormona. Cilj ovog rada bio je da primenom nearest neighbor matching analize utvrdi razliku u koncentraciji Hg kod zdravih/obolelih ispitanika od bolesti štitaste žlezde i da primenom Benchmark modelovanja utvrdi odnos doza-odgovor između nivoa Hg u krvi i tireostimulišućeg hormona (TSH) i tiroidnih hormona u serumu. Uzorci krvi su sakupljeni i korišćeni za merenje Hg uz pomoć ICP-MS metode, a izdvojeni serum korišćen je za analizu hormona. Studija je pokazala postojanje statistički značajne razlike u nivoima Hg koji su izmereni kod zdravih i bolesnih ispitanika i postojanje odnosa doza-odgovor između Hg i svih merenih hormona, pri čemu je uzak interval dobijen za Hg-TSH par. Rezultati ovog istraživanja podržavaju upotrebu Benchmark dose pristupa u svrhu analize podataka iz humanih studija, a naša dalja istraživanja će biti usmerena na ispitivanje uticaja niskih doza na životinjskim modelima, u cilju utvrđivanja preciznijih efekata niskih doza na organizam.", publisher = "Beograd : Savez farmaceutskih udruženja Srbije", journal = "Arhiv za farmaciju", title = "Exposure to mercury and thyroid function: Is there a connection?, Izloženost živi i funkcija štitaste žlezde: postoji li veza?", volume = "72", number = "5", pages = "468-485", doi = "10.5937/arhfarm72-40122" }
Marić, Đ., Bonderović, V., Javorac, D., Baralić, K., Bulat, Z., Đukić-Ćosić, D., Mandić-Rajčević, S., Žarković, M.,& Buha-Đorđević, A.. (2022). Exposure to mercury and thyroid function: Is there a connection?. in Arhiv za farmaciju Beograd : Savez farmaceutskih udruženja Srbije., 72(5), 468-485. https://doi.org/10.5937/arhfarm72-40122
Marić Đ, Bonderović V, Javorac D, Baralić K, Bulat Z, Đukić-Ćosić D, Mandić-Rajčević S, Žarković M, Buha-Đorđević A. Exposure to mercury and thyroid function: Is there a connection?. in Arhiv za farmaciju. 2022;72(5):468-485. doi:10.5937/arhfarm72-40122 .
Marić, Đurđica, Bonderović, Vera, Javorac, Dragana, Baralić, Katarina, Bulat, Zorica, Đukić-Ćosić, Danijela, Mandić-Rajčević, Stefan, Žarković, Miloš, Buha-Đorđević, Aleksandra, "Exposure to mercury and thyroid function: Is there a connection?" in Arhiv za farmaciju, 72, no. 5 (2022):468-485, https://doi.org/10.5937/arhfarm72-40122 . .