Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium
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Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and human medicine. Recently, interest in IVM has increased as it has been used for the treatment of some malignant diseases, as well as viral infections caused by the Zika virus, HIV-1 and SARS-CoV-2. The electrochemical behaviour of IVM was investigated using cyclic (CV), differential pulse (DPV) and square wave voltammetry (SWV) at glassy carbon electrode (GCE). IVM showed independent oxidation and reduction processes. The effect of pH and scan rate indicated the irreversibility of all processes and confirmed the diffusion character of oxidation and reduction as an adsorption-controlled process. Mechanisms for IVM oxidation at the tetrahydrofuran ring and reduction of the 1,4-diene structure in the IVM molecule are proposed. The redox behaviour of IVM in a biological matrix (human serum pool) showed a pronounced antioxidant potential similar to that of Trolox during short incubation, whereas a prolonged st...ay among biomolecules and in the presence of an exogenous pro-oxidant (tert-butyl hydroperoxide, TBH) resulted in a loss of its antioxidant effect. The antioxidant potential of IVM was confirmed by voltametric methodology which is proposed for the first time.
Кључне речи:
antioxidant and oxy-scores / glassy carbon electrode / ivermectin / oxidation and reduction mechanism / pro-oxidant / voltammetryИзвор:
Molecules, 2023, 28, 5Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/molecules28052113
ISSN: 1420-3049
PubMed: 36903359
WoS: 000947199500001
Scopus: 2-s2.0-85149831483
Институција/група
PharmacyTY - JOUR AU - Selaković, Milan AU - Aleksić, Mara AU - Kotur-Stevuljević, Jelena AU - Rupar, Jelena AU - Ivković, Branka PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4550 AB - Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and human medicine. Recently, interest in IVM has increased as it has been used for the treatment of some malignant diseases, as well as viral infections caused by the Zika virus, HIV-1 and SARS-CoV-2. The electrochemical behaviour of IVM was investigated using cyclic (CV), differential pulse (DPV) and square wave voltammetry (SWV) at glassy carbon electrode (GCE). IVM showed independent oxidation and reduction processes. The effect of pH and scan rate indicated the irreversibility of all processes and confirmed the diffusion character of oxidation and reduction as an adsorption-controlled process. Mechanisms for IVM oxidation at the tetrahydrofuran ring and reduction of the 1,4-diene structure in the IVM molecule are proposed. The redox behaviour of IVM in a biological matrix (human serum pool) showed a pronounced antioxidant potential similar to that of Trolox during short incubation, whereas a prolonged stay among biomolecules and in the presence of an exogenous pro-oxidant (tert-butyl hydroperoxide, TBH) resulted in a loss of its antioxidant effect. The antioxidant potential of IVM was confirmed by voltametric methodology which is proposed for the first time. PB - MDPI T2 - Molecules T1 - Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium VL - 28 IS - 5 DO - 10.3390/molecules28052113 ER -
@article{ author = "Selaković, Milan and Aleksić, Mara and Kotur-Stevuljević, Jelena and Rupar, Jelena and Ivković, Branka", year = "2023", abstract = "Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and human medicine. Recently, interest in IVM has increased as it has been used for the treatment of some malignant diseases, as well as viral infections caused by the Zika virus, HIV-1 and SARS-CoV-2. The electrochemical behaviour of IVM was investigated using cyclic (CV), differential pulse (DPV) and square wave voltammetry (SWV) at glassy carbon electrode (GCE). IVM showed independent oxidation and reduction processes. The effect of pH and scan rate indicated the irreversibility of all processes and confirmed the diffusion character of oxidation and reduction as an adsorption-controlled process. Mechanisms for IVM oxidation at the tetrahydrofuran ring and reduction of the 1,4-diene structure in the IVM molecule are proposed. The redox behaviour of IVM in a biological matrix (human serum pool) showed a pronounced antioxidant potential similar to that of Trolox during short incubation, whereas a prolonged stay among biomolecules and in the presence of an exogenous pro-oxidant (tert-butyl hydroperoxide, TBH) resulted in a loss of its antioxidant effect. The antioxidant potential of IVM was confirmed by voltametric methodology which is proposed for the first time.", publisher = "MDPI", journal = "Molecules", title = "Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium", volume = "28", number = "5", doi = "10.3390/molecules28052113" }
Selaković, M., Aleksić, M., Kotur-Stevuljević, J., Rupar, J.,& Ivković, B.. (2023). Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium. in Molecules MDPI., 28(5). https://doi.org/10.3390/molecules28052113
Selaković M, Aleksić M, Kotur-Stevuljević J, Rupar J, Ivković B. Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium. in Molecules. 2023;28(5). doi:10.3390/molecules28052113 .
Selaković, Milan, Aleksić, Mara, Kotur-Stevuljević, Jelena, Rupar, Jelena, Ivković, Branka, "Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium" in Molecules, 28, no. 5 (2023), https://doi.org/10.3390/molecules28052113 . .