Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats
Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova
Аутори
Ćurčić, MarijanaJanković, Saša
Buha-Đorđević, Aleksandra
Milovanović, Vesna
Antonijević-Miljaković, Evica
Đukić-Ćosić, Danijela
Javorac, Dragana
Baralić, Katarina
Živančević, Katarina
Božić, Dragica
Durgo, Ksenija
Vučinić, Slavica
Bulat, Zorica
Antonijević, Biljana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1....713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd.
Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznos...i 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.
Извор:
Arhiv za farmaciju, 2022, 72, 4 suplement, S575-S576Издавач:
- Savez farmaceutskih udruženja Srbije (SFUS)
Напомена:
- VIII Kongres farmaceuta Srbije sa međunarodnim učešćem, 12-15.10.2022. Beograd
Институција/група
PharmacyTY - CONF AU - Ćurčić, Marijana AU - Janković, Saša AU - Buha-Đorđević, Aleksandra AU - Milovanović, Vesna AU - Antonijević-Miljaković, Evica AU - Đukić-Ćosić, Danijela AU - Javorac, Dragana AU - Baralić, Katarina AU - Živančević, Katarina AU - Božić, Dragica AU - Durgo, Ksenija AU - Vučinić, Slavica AU - Bulat, Zorica AU - Antonijević, Biljana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4626 AB - Humans are exposed to the chemicals from very different sources. Therefore, the exposure assessment should be focused on mixtures rather than single chemicals. In this study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely spread persistent environmental pollutants, has been evaluated. In order to evaluate the potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the dose-response curves slopes and lower confidence limit of Benchmark dose of 10% (BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of 5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10 times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a major role in the blood cells creation and health of other systems, our results indicate more potent activity of the mixture than single Cd. AB - Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15 mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713 mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL 10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd. PB - Savez farmaceutskih udruženja Srbije (SFUS) C3 - Arhiv za farmaciju T1 - Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats T1 - Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova VL - 72 IS - 4 suplement SP - S575 EP - S576 UR - https://hdl.handle.net/21.15107/rcub_farfar_4626 ER -
@conference{ author = "Ćurčić, Marijana and Janković, Saša and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Durgo, Ksenija and Vučinić, Slavica and Bulat, Zorica and Antonijević, Biljana", year = "2022", abstract = "Humans are exposed to the chemicals from very different sources. Therefore, the exposure assessment should be focused on mixtures rather than single chemicals. In this study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely spread persistent environmental pollutants, has been evaluated. In order to evaluate the potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the dose-response curves slopes and lower confidence limit of Benchmark dose of 10% (BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of 5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10 times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a major role in the blood cells creation and health of other systems, our results indicate more potent activity of the mixture than single Cd., Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15 mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713 mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL 10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.", publisher = "Savez farmaceutskih udruženja Srbije (SFUS)", journal = "Arhiv za farmaciju", title = "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats, Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova", volume = "72", number = "4 suplement", pages = "S575-S576", url = "https://hdl.handle.net/21.15107/rcub_farfar_4626" }
Ćurčić, M., Janković, S., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Živančević, K., Božić, D., Durgo, K., Vučinić, S., Bulat, Z.,& Antonijević, B.. (2022). Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S575-S576. https://hdl.handle.net/21.15107/rcub_farfar_4626
Ćurčić M, Janković S, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Živančević K, Božić D, Durgo K, Vučinić S, Bulat Z, Antonijević B. Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju. 2022;72(4 suplement):S575-S576. https://hdl.handle.net/21.15107/rcub_farfar_4626 .
Ćurčić, Marijana, Janković, Saša, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Durgo, Ksenija, Vučinić, Slavica, Bulat, Zorica, Antonijević, Biljana, "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S575-S576, https://hdl.handle.net/21.15107/rcub_farfar_4626 .