The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels
Само за регистроване кориснике
2023
Аутори
Sarić-Matutinović, MarijaKahaly, G.J.
Žarković, Miloš
Ćirić, J.
Ignjatović, Svetlana
Nedeljković Beleslin, B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose: Graves’ orbitopathy (GO) is a specific inflammatory disorder of the orbit characterized by a highly heterogeneous clinical phenotype. The role of thyrotropin receptor antibodies (TSH-R-Ab) has been widely researched, however there is still no evidence that these antibodies have a direct pathogenic role in this pathology. The aim of this study was to examine their relation to the individual clinical features of GO. Methods: Ninety-one consecutive patients with GO were recruited. Total antibody concentration (TSH-R binding inhibitory immunoglobulins, TBII) and their functional activity (stimulating TSH-R-Ab, TSAb) were measured using binding immunoassay and cell-based bioassay, respectively. Results: Both TSAb and TBII levels were significantly associated to the clinical parameters of GO activity. TSAb was a more sensitive serological marker compared to TBII pertaining to eyelid retraction and edema, proptosis, extra-orbital muscle disorders, diplopia, irritable eye symptoms, an...d photophobia. TSAb, but not TBII, was a significant predictive marker of conjunctival redness, chemosis, caruncle/plica inflammation, eye irritation, and orbital pain, (odds ratio: 3.096, p = 0.016; 5.833, p = 0.009; 6.443, p = 0.020; 3.167, p = 0.045; 2.893, p = 0.032; versus 2.187, p = 0.093; 2.775, p = 0.081; 3.824, p = 0.055; 0.952, p = 0.930; 2.226, p = 0.099, respectively). Neither TSAb nor TBII correlated with the level of proptosis (ρ = 0.259, p = 0.090, and ρ = 0.254, p = 0.104, respectively), however rising TSAb levels were strongly associated to the level of proptosis. Conclusions: TSH-R-Ab were significantly associated with GO’s phenotype. Especially TSAb, as a sensitive and predictive serological biomarker, can improve diagnosis and management of GO.
Кључне речи:
Binding immunoassay / Cell-based bioassay / Graves’ orbitopathy / Ophthalmological features / Stimulating antibodies / Thyrotropin receptor antibodiesИзвор:
Journal of Endocrinological Investigation, 2023Издавач:
- Springer Science and Business Media
Финансирање / пројекти:
- Биомаркери оштећења и дисфункције органа (RS-MESTD-Basic Research (BR or ON)-175036)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1007/s40618-023-02085-5
ISSN: 0391-4097
PubMed: 37020104
WoS: 000963641400002
Scopus: 2-s2.0-85151504022
Институција/група
PharmacyTY - JOUR AU - Sarić-Matutinović, Marija AU - Kahaly, G.J. AU - Žarković, Miloš AU - Ćirić, J. AU - Ignjatović, Svetlana AU - Nedeljković Beleslin, B. PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4654 AB - Purpose: Graves’ orbitopathy (GO) is a specific inflammatory disorder of the orbit characterized by a highly heterogeneous clinical phenotype. The role of thyrotropin receptor antibodies (TSH-R-Ab) has been widely researched, however there is still no evidence that these antibodies have a direct pathogenic role in this pathology. The aim of this study was to examine their relation to the individual clinical features of GO. Methods: Ninety-one consecutive patients with GO were recruited. Total antibody concentration (TSH-R binding inhibitory immunoglobulins, TBII) and their functional activity (stimulating TSH-R-Ab, TSAb) were measured using binding immunoassay and cell-based bioassay, respectively. Results: Both TSAb and TBII levels were significantly associated to the clinical parameters of GO activity. TSAb was a more sensitive serological marker compared to TBII pertaining to eyelid retraction and edema, proptosis, extra-orbital muscle disorders, diplopia, irritable eye symptoms, and photophobia. TSAb, but not TBII, was a significant predictive marker of conjunctival redness, chemosis, caruncle/plica inflammation, eye irritation, and orbital pain, (odds ratio: 3.096, p = 0.016; 5.833, p = 0.009; 6.443, p = 0.020; 3.167, p = 0.045; 2.893, p = 0.032; versus 2.187, p = 0.093; 2.775, p = 0.081; 3.824, p = 0.055; 0.952, p = 0.930; 2.226, p = 0.099, respectively). Neither TSAb nor TBII correlated with the level of proptosis (ρ = 0.259, p = 0.090, and ρ = 0.254, p = 0.104, respectively), however rising TSAb levels were strongly associated to the level of proptosis. Conclusions: TSH-R-Ab were significantly associated with GO’s phenotype. Especially TSAb, as a sensitive and predictive serological biomarker, can improve diagnosis and management of GO. PB - Springer Science and Business Media T2 - Journal of Endocrinological Investigation T1 - The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels DO - 10.1007/s40618-023-02085-5 ER -
@article{ author = "Sarić-Matutinović, Marija and Kahaly, G.J. and Žarković, Miloš and Ćirić, J. and Ignjatović, Svetlana and Nedeljković Beleslin, B.", year = "2023", abstract = "Purpose: Graves’ orbitopathy (GO) is a specific inflammatory disorder of the orbit characterized by a highly heterogeneous clinical phenotype. The role of thyrotropin receptor antibodies (TSH-R-Ab) has been widely researched, however there is still no evidence that these antibodies have a direct pathogenic role in this pathology. The aim of this study was to examine their relation to the individual clinical features of GO. Methods: Ninety-one consecutive patients with GO were recruited. Total antibody concentration (TSH-R binding inhibitory immunoglobulins, TBII) and their functional activity (stimulating TSH-R-Ab, TSAb) were measured using binding immunoassay and cell-based bioassay, respectively. Results: Both TSAb and TBII levels were significantly associated to the clinical parameters of GO activity. TSAb was a more sensitive serological marker compared to TBII pertaining to eyelid retraction and edema, proptosis, extra-orbital muscle disorders, diplopia, irritable eye symptoms, and photophobia. TSAb, but not TBII, was a significant predictive marker of conjunctival redness, chemosis, caruncle/plica inflammation, eye irritation, and orbital pain, (odds ratio: 3.096, p = 0.016; 5.833, p = 0.009; 6.443, p = 0.020; 3.167, p = 0.045; 2.893, p = 0.032; versus 2.187, p = 0.093; 2.775, p = 0.081; 3.824, p = 0.055; 0.952, p = 0.930; 2.226, p = 0.099, respectively). Neither TSAb nor TBII correlated with the level of proptosis (ρ = 0.259, p = 0.090, and ρ = 0.254, p = 0.104, respectively), however rising TSAb levels were strongly associated to the level of proptosis. Conclusions: TSH-R-Ab were significantly associated with GO’s phenotype. Especially TSAb, as a sensitive and predictive serological biomarker, can improve diagnosis and management of GO.", publisher = "Springer Science and Business Media", journal = "Journal of Endocrinological Investigation", title = "The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels", doi = "10.1007/s40618-023-02085-5" }
Sarić-Matutinović, M., Kahaly, G.J., Žarković, M., Ćirić, J., Ignjatović, S.,& Nedeljković Beleslin, B.. (2023). The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels. in Journal of Endocrinological Investigation Springer Science and Business Media.. https://doi.org/10.1007/s40618-023-02085-5
Sarić-Matutinović M, Kahaly G, Žarković M, Ćirić J, Ignjatović S, Nedeljković Beleslin B. The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels. in Journal of Endocrinological Investigation. 2023;. doi:10.1007/s40618-023-02085-5 .
Sarić-Matutinović, Marija, Kahaly, G.J., Žarković, Miloš, Ćirić, J., Ignjatović, Svetlana, Nedeljković Beleslin, B., "The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels" in Journal of Endocrinological Investigation (2023), https://doi.org/10.1007/s40618-023-02085-5 . .