LncRNAs as Regulators of Atherosclerotic Plaque Stability
Аутори
Petković, AleksaErceg, Sanja
Munjas, Jelena
Ninić, Ana
Vladimirov, Sandra
Davidović, Aleksandar
Vukmirović, Luka
Milanov, Marko
Cvijanović, Dane
Mitić, Tijana
Sopić, Miron
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced and unstable atherosclerotic plaques most often trigger acute coronary events that can lead to fatal outcomes. However, despite the fact that different plaque phenotypes may require different treatments, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes. Long non-coding RNAs (lncRNAs) represent an important class of molecules that are implicated in epigenetic control of numerous cellular processes. Here we review the latest knowledge about lncRNAs’ influence on plaque development and stability through regulation of immune response, lipid metabolism, extracellular matrix remodelling, endothelial cell function, and vascular smooth muscle function, with special emphasis on pro-ath...erogenic and anti-atherogenic lncRNA functions. In addition, we present current challenges in the research of lncRNAs’ role in atherosclerosis and translation of the findings from animal models to humans. Finally, we present the directions for future lncRNA-oriented research, which may ultimately result in patient-oriented therapeutic strategies for ASCVD.
Кључне речи:
atherosclerosis / long non-coding RNAs / plaque stabilityИзвор:
Cells, 2023, 12, 14Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- HI-MOM - HIgh-density lipoprotein MetabolOMe research to improve pregnancy outcome (RS-ScienceFundRS-Ideje-7741659)
- European Union (HORIZON-MSCA-2021-SE-01-01—MSCA Staff Exchanges 2021 CardioSCOPE 10108639
- British Heart Foundation (BHF) Career Re-entry Fellowship (FS/16/38/32351)
- European Union AtheroNET COST Action CA21153
DOI: 10.3390/cells12141832
ISSN: 2073-4409
PubMed: 37508497
WoS: 001038163200001
Scopus: 2-s2.0-85165980661
Институција/група
PharmacyTY - JOUR AU - Petković, Aleksa AU - Erceg, Sanja AU - Munjas, Jelena AU - Ninić, Ana AU - Vladimirov, Sandra AU - Davidović, Aleksandar AU - Vukmirović, Luka AU - Milanov, Marko AU - Cvijanović, Dane AU - Mitić, Tijana AU - Sopić, Miron PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4955 AB - Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced and unstable atherosclerotic plaques most often trigger acute coronary events that can lead to fatal outcomes. However, despite the fact that different plaque phenotypes may require different treatments, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes. Long non-coding RNAs (lncRNAs) represent an important class of molecules that are implicated in epigenetic control of numerous cellular processes. Here we review the latest knowledge about lncRNAs’ influence on plaque development and stability through regulation of immune response, lipid metabolism, extracellular matrix remodelling, endothelial cell function, and vascular smooth muscle function, with special emphasis on pro-atherogenic and anti-atherogenic lncRNA functions. In addition, we present current challenges in the research of lncRNAs’ role in atherosclerosis and translation of the findings from animal models to humans. Finally, we present the directions for future lncRNA-oriented research, which may ultimately result in patient-oriented therapeutic strategies for ASCVD. PB - MDPI T2 - Cells T1 - LncRNAs as Regulators of Atherosclerotic Plaque Stability VL - 12 IS - 14 DO - 10.3390/cells12141832 ER -
@article{ author = "Petković, Aleksa and Erceg, Sanja and Munjas, Jelena and Ninić, Ana and Vladimirov, Sandra and Davidović, Aleksandar and Vukmirović, Luka and Milanov, Marko and Cvijanović, Dane and Mitić, Tijana and Sopić, Miron", year = "2023", abstract = "Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced and unstable atherosclerotic plaques most often trigger acute coronary events that can lead to fatal outcomes. However, despite the fact that different plaque phenotypes may require different treatments, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes. Long non-coding RNAs (lncRNAs) represent an important class of molecules that are implicated in epigenetic control of numerous cellular processes. Here we review the latest knowledge about lncRNAs’ influence on plaque development and stability through regulation of immune response, lipid metabolism, extracellular matrix remodelling, endothelial cell function, and vascular smooth muscle function, with special emphasis on pro-atherogenic and anti-atherogenic lncRNA functions. In addition, we present current challenges in the research of lncRNAs’ role in atherosclerosis and translation of the findings from animal models to humans. Finally, we present the directions for future lncRNA-oriented research, which may ultimately result in patient-oriented therapeutic strategies for ASCVD.", publisher = "MDPI", journal = "Cells", title = "LncRNAs as Regulators of Atherosclerotic Plaque Stability", volume = "12", number = "14", doi = "10.3390/cells12141832" }
Petković, A., Erceg, S., Munjas, J., Ninić, A., Vladimirov, S., Davidović, A., Vukmirović, L., Milanov, M., Cvijanović, D., Mitić, T.,& Sopić, M.. (2023). LncRNAs as Regulators of Atherosclerotic Plaque Stability. in Cells MDPI., 12(14). https://doi.org/10.3390/cells12141832
Petković A, Erceg S, Munjas J, Ninić A, Vladimirov S, Davidović A, Vukmirović L, Milanov M, Cvijanović D, Mitić T, Sopić M. LncRNAs as Regulators of Atherosclerotic Plaque Stability. in Cells. 2023;12(14). doi:10.3390/cells12141832 .
Petković, Aleksa, Erceg, Sanja, Munjas, Jelena, Ninić, Ana, Vladimirov, Sandra, Davidović, Aleksandar, Vukmirović, Luka, Milanov, Marko, Cvijanović, Dane, Mitić, Tijana, Sopić, Miron, "LncRNAs as Regulators of Atherosclerotic Plaque Stability" in Cells, 12, no. 14 (2023), https://doi.org/10.3390/cells12141832 . .