Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Аутори
Filipić, BrankicaPantelić, Ivana
Nikolić, Ines
Majhen, Dragomira
Stojić-Vukanić, Zorica
Savić, Snežana
Krajišnik, Danina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vect...ors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases.
Кључне речи:
nanoemulsions / nanoadjuvants / viral-vectored system / virus-like particlesИзвор:
Vaccines, 2023, 11, 7Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- Croatian Science Foundation, grant number IP-2019-04-6048
- COST Action CA16231 European Network of Vaccine Adjuvants (ENOVA)
DOI: 10.3390/vaccines11071172
ISSN: 2076-393X
PubMed: 37514991
WoS: 001038882700001
Scopus: 2-s2.0-85166427548
Институција/група
PharmacyTY - JOUR AU - Filipić, Brankica AU - Pantelić, Ivana AU - Nikolić, Ines AU - Majhen, Dragomira AU - Stojić-Vukanić, Zorica AU - Savić, Snežana AU - Krajišnik, Danina PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4960 AB - Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases. PB - MDPI T2 - Vaccines T1 - Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines VL - 11 IS - 7 DO - 10.3390/vaccines11071172 ER -
@article{ author = "Filipić, Brankica and Pantelić, Ivana and Nikolić, Ines and Majhen, Dragomira and Stojić-Vukanić, Zorica and Savić, Snežana and Krajišnik, Danina", year = "2023", abstract = "Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases.", publisher = "MDPI", journal = "Vaccines", title = "Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines", volume = "11", number = "7", doi = "10.3390/vaccines11071172" }
Filipić, B., Pantelić, I., Nikolić, I., Majhen, D., Stojić-Vukanić, Z., Savić, S.,& Krajišnik, D.. (2023). Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines. in Vaccines MDPI., 11(7). https://doi.org/10.3390/vaccines11071172
Filipić B, Pantelić I, Nikolić I, Majhen D, Stojić-Vukanić Z, Savić S, Krajišnik D. Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines. in Vaccines. 2023;11(7). doi:10.3390/vaccines11071172 .
Filipić, Brankica, Pantelić, Ivana, Nikolić, Ines, Majhen, Dragomira, Stojić-Vukanić, Zorica, Savić, Snežana, Krajišnik, Danina, "Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines" in Vaccines, 11, no. 7 (2023), https://doi.org/10.3390/vaccines11071172 . .