Resource management in HPLC: Unveiling a green face of pharmaceutical analysis
Upravljanje resursima u HPLC: Otkrivanje zelenog lica farmaceutske analize
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High-pressure liquid chromatography (HPLC) is a technique of paramount importance in
the analysis of pharmaceuticals because of its ability to separate moderately polar to less polar
compounds, such as drugs and related substances. The concept of green analytical chemistry
(GAC) aims to provide more environmentally friendly and safer analytical methods in terms of
reagents, energy, and waste. One of the major challenges of GAC is to find an appropriate
approach to evaluate the greenness of analytical methods. An extension of GAC, called white
analytical chemistry (WAC), has been introduced to consider not only environmental friendliness,
but also other aspects that contribute to the sustainability of methods, such as analytical and
economic or practical efficiency. HPLC methods are intrinsically not green, due to the high
consumption of toxic organic solvents and the resulting generation of large amounts of toxic
waste. Fortunately, there are many approaches to overcome the n...on-green character of HPLC
methods. In this article, various modifications of the HPLC methods that increase its
environmental friendliness are presented, as well as the various tools used to evaluate
environmental friendliness. In addition, the new concept of white analytical chemistry is
presented.
Tečna hromatografija pod visokim pritiskom (HPLC) je tehnika od ogromne važnosti u analitici lekova zbog svoje mogućnosti da razdvoji umereno do manje polarna jedinjenja, kao što su aktivne farmaceutske i srodne supstance. Koncept zelene analitičke hemije (GAC) ima za cilj da obezbedi ekološki prihvatljivije i bezbednije metode u pogledu reagenasa, energije i otpada. Jedan od glavnih izazova GAC je da pronađe odgovarajući pristup za procenu "zelenosti" analitičkih metoda. Proširenje GAC, nazvano bela analitička hemija (WAC), uvedeno je kako bi se uzela u obzir ne samo ekološka prihvatljivost, već i drugi aspekti koji doprinose održivosti metoda, kao što su analitička i ekonomska ili praktična efikasnost. HPLC metode suštinski nisu "zelene" zbog obimne potrošnje toksičnih organskih rastvarača i posledičnog stvaranja velikih količina toksičnog otpada. Srećom, postoji mnogo pristupa za prevazilaženje ne-zelene prirode HPLC metoda. U ovom radu su predstavljene različite modifikacije HPLC m...etode koje povećavaju ekološku prihvatljivost, kao i različiti alati koji se koriste za procenu ekološke prihvatljivosti. Pored toga, predstavljen je novi koncept bele analitičke hemije.
Кључне речи:
high-performance liquid chromatography / greenness assessment / sustainability / tečna hromatografija visokih performansi / procena ekološke prihvatljivosti metoda / održivostИзвор:
Arhiv za farmaciju, 2023, 73, 2, 146-171Издавач:
- Savez farmaceutskih udruženja Srbije (SFUS)
Институција/група
PharmacyTY - JOUR AU - Stojanović, Jevrem AU - Krmar, Jovana AU - Otašević, Biljana AU - Protić, Ana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4976 AB - High-pressure liquid chromatography (HPLC) is a technique of paramount importance in the analysis of pharmaceuticals because of its ability to separate moderately polar to less polar compounds, such as drugs and related substances. The concept of green analytical chemistry (GAC) aims to provide more environmentally friendly and safer analytical methods in terms of reagents, energy, and waste. One of the major challenges of GAC is to find an appropriate approach to evaluate the greenness of analytical methods. An extension of GAC, called white analytical chemistry (WAC), has been introduced to consider not only environmental friendliness, but also other aspects that contribute to the sustainability of methods, such as analytical and economic or practical efficiency. HPLC methods are intrinsically not green, due to the high consumption of toxic organic solvents and the resulting generation of large amounts of toxic waste. Fortunately, there are many approaches to overcome the non-green character of HPLC methods. In this article, various modifications of the HPLC methods that increase its environmental friendliness are presented, as well as the various tools used to evaluate environmental friendliness. In addition, the new concept of white analytical chemistry is presented. AB - Tečna hromatografija pod visokim pritiskom (HPLC) je tehnika od ogromne važnosti u analitici lekova zbog svoje mogućnosti da razdvoji umereno do manje polarna jedinjenja, kao što su aktivne farmaceutske i srodne supstance. Koncept zelene analitičke hemije (GAC) ima za cilj da obezbedi ekološki prihvatljivije i bezbednije metode u pogledu reagenasa, energije i otpada. Jedan od glavnih izazova GAC je da pronađe odgovarajući pristup za procenu "zelenosti" analitičkih metoda. Proširenje GAC, nazvano bela analitička hemija (WAC), uvedeno je kako bi se uzela u obzir ne samo ekološka prihvatljivost, već i drugi aspekti koji doprinose održivosti metoda, kao što su analitička i ekonomska ili praktična efikasnost. HPLC metode suštinski nisu "zelene" zbog obimne potrošnje toksičnih organskih rastvarača i posledičnog stvaranja velikih količina toksičnog otpada. Srećom, postoji mnogo pristupa za prevazilaženje ne-zelene prirode HPLC metoda. U ovom radu su predstavljene različite modifikacije HPLC metode koje povećavaju ekološku prihvatljivost, kao i različiti alati koji se koriste za procenu ekološke prihvatljivosti. Pored toga, predstavljen je novi koncept bele analitičke hemije. PB - Savez farmaceutskih udruženja Srbije (SFUS) T2 - Arhiv za farmaciju T1 - Resource management in HPLC: Unveiling a green face of pharmaceutical analysis T1 - Upravljanje resursima u HPLC: Otkrivanje zelenog lica farmaceutske analize VL - 73 IS - 2 SP - 146 EP - 171 DO - 10.5937/arhfarm73-43479 ER -
@article{ author = "Stojanović, Jevrem and Krmar, Jovana and Otašević, Biljana and Protić, Ana", year = "2023", abstract = "High-pressure liquid chromatography (HPLC) is a technique of paramount importance in the analysis of pharmaceuticals because of its ability to separate moderately polar to less polar compounds, such as drugs and related substances. The concept of green analytical chemistry (GAC) aims to provide more environmentally friendly and safer analytical methods in terms of reagents, energy, and waste. One of the major challenges of GAC is to find an appropriate approach to evaluate the greenness of analytical methods. An extension of GAC, called white analytical chemistry (WAC), has been introduced to consider not only environmental friendliness, but also other aspects that contribute to the sustainability of methods, such as analytical and economic or practical efficiency. HPLC methods are intrinsically not green, due to the high consumption of toxic organic solvents and the resulting generation of large amounts of toxic waste. Fortunately, there are many approaches to overcome the non-green character of HPLC methods. In this article, various modifications of the HPLC methods that increase its environmental friendliness are presented, as well as the various tools used to evaluate environmental friendliness. In addition, the new concept of white analytical chemistry is presented., Tečna hromatografija pod visokim pritiskom (HPLC) je tehnika od ogromne važnosti u analitici lekova zbog svoje mogućnosti da razdvoji umereno do manje polarna jedinjenja, kao što su aktivne farmaceutske i srodne supstance. Koncept zelene analitičke hemije (GAC) ima za cilj da obezbedi ekološki prihvatljivije i bezbednije metode u pogledu reagenasa, energije i otpada. Jedan od glavnih izazova GAC je da pronađe odgovarajući pristup za procenu "zelenosti" analitičkih metoda. Proširenje GAC, nazvano bela analitička hemija (WAC), uvedeno je kako bi se uzela u obzir ne samo ekološka prihvatljivost, već i drugi aspekti koji doprinose održivosti metoda, kao što su analitička i ekonomska ili praktična efikasnost. HPLC metode suštinski nisu "zelene" zbog obimne potrošnje toksičnih organskih rastvarača i posledičnog stvaranja velikih količina toksičnog otpada. Srećom, postoji mnogo pristupa za prevazilaženje ne-zelene prirode HPLC metoda. U ovom radu su predstavljene različite modifikacije HPLC metode koje povećavaju ekološku prihvatljivost, kao i različiti alati koji se koriste za procenu ekološke prihvatljivosti. Pored toga, predstavljen je novi koncept bele analitičke hemije.", publisher = "Savez farmaceutskih udruženja Srbije (SFUS)", journal = "Arhiv za farmaciju", title = "Resource management in HPLC: Unveiling a green face of pharmaceutical analysis, Upravljanje resursima u HPLC: Otkrivanje zelenog lica farmaceutske analize", volume = "73", number = "2", pages = "146-171", doi = "10.5937/arhfarm73-43479" }
Stojanović, J., Krmar, J., Otašević, B.,& Protić, A.. (2023). Resource management in HPLC: Unveiling a green face of pharmaceutical analysis. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije (SFUS)., 73(2), 146-171. https://doi.org/10.5937/arhfarm73-43479
Stojanović J, Krmar J, Otašević B, Protić A. Resource management in HPLC: Unveiling a green face of pharmaceutical analysis. in Arhiv za farmaciju. 2023;73(2):146-171. doi:10.5937/arhfarm73-43479 .
Stojanović, Jevrem, Krmar, Jovana, Otašević, Biljana, Protić, Ana, "Resource management in HPLC: Unveiling a green face of pharmaceutical analysis" in Arhiv za farmaciju, 73, no. 2 (2023):146-171, https://doi.org/10.5937/arhfarm73-43479 . .