Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling
Аутори
Nikolić, KatarinaVučićević, Jelica
Popović, Marija
Filipić, Slavica
Obradović, Darija
Dobričić, Vladimir
Agbaba, Danica
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Imidazoline receptor ligands are a numerous
family of biologically active compounds
known to produce central hypotensive effect
by interaction with both alpha2-adrenoreceptors
(alpha2-AR) and imidazoline receptors (IRs) (1,
2).
The main aims of this study were to evaluate
Blood-Brain Barrier (BBB) permeability (Pe)
of 18 IRs/alpha-ARs ligands and 22 Central
Nervous System (CNS) drugs using Parallel
Artificial Membrane Permeability Assay
(PAMPA) and Biopartitioning Micellar
Chromatography (BMC), and than to develop
the Quantitative-Structure-Permeability
Relationship (QSPR) models useful for
prediction BBB permeability of related IRs/alpha-
ARs ligands.
Извор:
Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia, 2016, 66, 25-26Издавач:
- Savez farmaceutskih udruženja Srbije, Beograd
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
Напомена:
- 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia
Институција/група
PharmacyTY - CONF AU - Nikolić, Katarina AU - Vučićević, Jelica AU - Popović, Marija AU - Filipić, Slavica AU - Obradović, Darija AU - Dobričić, Vladimir AU - Agbaba, Danica PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5027 AB - Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both alpha2-adrenoreceptors (alpha2-AR) and imidazoline receptors (IRs) (1, 2). The main aims of this study were to evaluate Blood-Brain Barrier (BBB) permeability (Pe) of 18 IRs/alpha-ARs ligands and 22 Central Nervous System (CNS) drugs using Parallel Artificial Membrane Permeability Assay (PAMPA) and Biopartitioning Micellar Chromatography (BMC), and than to develop the Quantitative-Structure-Permeability Relationship (QSPR) models useful for prediction BBB permeability of related IRs/alpha- ARs ligands. PB - Savez farmaceutskih udruženja Srbije, Beograd C3 - Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia T1 - Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling VL - 66 SP - 25 EP - 26 UR - https://hdl.handle.net/21.15107/rcub_farfar_5027 ER -
@conference{ author = "Nikolić, Katarina and Vučićević, Jelica and Popović, Marija and Filipić, Slavica and Obradović, Darija and Dobričić, Vladimir and Agbaba, Danica", year = "2016", abstract = "Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both alpha2-adrenoreceptors (alpha2-AR) and imidazoline receptors (IRs) (1, 2). The main aims of this study were to evaluate Blood-Brain Barrier (BBB) permeability (Pe) of 18 IRs/alpha-ARs ligands and 22 Central Nervous System (CNS) drugs using Parallel Artificial Membrane Permeability Assay (PAMPA) and Biopartitioning Micellar Chromatography (BMC), and than to develop the Quantitative-Structure-Permeability Relationship (QSPR) models useful for prediction BBB permeability of related IRs/alpha- ARs ligands.", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia", title = "Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling", volume = "66", pages = "25-26", url = "https://hdl.handle.net/21.15107/rcub_farfar_5027" }
Nikolić, K., Vučićević, J., Popović, M., Filipić, S., Obradović, D., Dobričić, V.,& Agbaba, D.. (2016). Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling. in Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia Savez farmaceutskih udruženja Srbije, Beograd., 66, 25-26. https://hdl.handle.net/21.15107/rcub_farfar_5027
Nikolić K, Vučićević J, Popović M, Filipić S, Obradović D, Dobričić V, Agbaba D. Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling. in Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia. 2016;66:25-26. https://hdl.handle.net/21.15107/rcub_farfar_5027 .
Nikolić, Katarina, Vučićević, Jelica, Popović, Marija, Filipić, Slavica, Obradović, Darija, Dobričić, Vladimir, Agbaba, Danica, "Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling" in Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia, 66 (2016):25-26, https://hdl.handle.net/21.15107/rcub_farfar_5027 .