From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
Аутори
Aleksić, IvanaĆirin-Varađan, Slobodanka
Glišić, Teodora
Petrović, Nađa
Đuriš, Jelena
Parojčić, Jelena
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.
Извор:
Macedonian Pharmaceutical Bulletin, 2023, 69, Suppl 1, 139-140Издавач:
- Macedonian Pharmaceutical Association
- Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Напомена:
- 14th Central European Symposium on Pharmaceutical Technology, 28th - 30th September, Ohrid, N. Macedonia, 2023
Институција/група
PharmacyTY - CONF AU - Aleksić, Ivana AU - Ćirin-Varađan, Slobodanka AU - Glišić, Teodora AU - Petrović, Nađa AU - Đuriš, Jelena AU - Parojčić, Jelena PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5067 AB - Direct compression, as the simplest and therefore preferable method of tableting, is often hindered by poor flow and compaction properties of the active pharmaceutical ingredient (API). Tableting by direct compression is particularly challenging when high API loading is required. The use of co-processed excipients can result in a robust directly compressible formulation, while melt granulation has emerged as an environmentally friendly co-processing method that can result in highly functional co-processed excipients (Ćirin-Varađan et al, 2022). The aim of the present study was to investigate the suitability of lactose co-processed with glyceryl palmitostearate for the preparation of a directly compressible formulation of ibuprofen, a challenging high- dose API. The influence of initial particle size of glyceryl palmitostearate, ibuprofen content and compression parameters on compaction behavior of tableting mixtures was investigated. PB - Macedonian Pharmaceutical Association PB - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy C3 - Macedonian Pharmaceutical Bulletin T1 - From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations VL - 69 IS - Suppl 1 SP - 139 EP - 140 DO - 10.33320/maced.pharm.bull.2023.69.03.068 ER -
@conference{ author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Petrović, Nađa and Đuriš, Jelena and Parojčić, Jelena", year = "2023", abstract = "Direct compression, as the simplest and therefore preferable method of tableting, is often hindered by poor flow and compaction properties of the active pharmaceutical ingredient (API). Tableting by direct compression is particularly challenging when high API loading is required. The use of co-processed excipients can result in a robust directly compressible formulation, while melt granulation has emerged as an environmentally friendly co-processing method that can result in highly functional co-processed excipients (Ćirin-Varađan et al, 2022). The aim of the present study was to investigate the suitability of lactose co-processed with glyceryl palmitostearate for the preparation of a directly compressible formulation of ibuprofen, a challenging high- dose API. The influence of initial particle size of glyceryl palmitostearate, ibuprofen content and compression parameters on compaction behavior of tableting mixtures was investigated.", publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy", journal = "Macedonian Pharmaceutical Bulletin", title = "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations", volume = "69", number = "Suppl 1", pages = "139-140", doi = "10.33320/maced.pharm.bull.2023.69.03.068" }
Aleksić, I., Ćirin-Varađan, S., Glišić, T., Petrović, N., Đuriš, J.,& Parojčić, J.. (2023). From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin Macedonian Pharmaceutical Association., 69(Suppl 1), 139-140. https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068
Aleksić I, Ćirin-Varađan S, Glišić T, Petrović N, Đuriš J, Parojčić J. From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):139-140. doi:10.33320/maced.pharm.bull.2023.69.03.068 .
Aleksić, Ivana, Ćirin-Varađan, Slobodanka, Glišić, Teodora, Petrović, Nađa, Đuriš, Jelena, Parojčić, Jelena, "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):139-140, https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068 . .