The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban
Аутори
Vasiljević, IvanaPasik, Paulina
Turković, Erna
Ivković, Branka
Hejduk, Arkadiusz
Lulek, Janina
Parojčić, Jelena
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly in the case of challenging model drugs.
Rivaroxaban is classified as a class II model drug
according to the Biopharmaceutical Classification System
and exhibits prominent cohesiveness and low aqueous
solubility (Choi et al., 2022). The aim of this work was to
evaluate the influence of different directly compressible
fillers/diluents on selected compact properties (namely,
tensile strength, friability, and disintegration) and the
dissolution of rivaroxaban from the prepared compacts.
Извор:
Macedonian Pharmaceutical Bulletin, 2023, 69, Suppl 1, 289-290Издавач:
- Macedonian Pharmaceutical Association
- Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- CEEPUS M-RS-1113-2223-164611
- M- RS-1113-2223-165837
Напомена:
- 14th Central European Symposium on Pharmaceutical Technology, 28th - 30th September, Ohrid, N. Macedonia, 2023
Институција/група
PharmacyTY - CONF AU - Vasiljević, Ivana AU - Pasik, Paulina AU - Turković, Erna AU - Ivković, Branka AU - Hejduk, Arkadiusz AU - Lulek, Janina AU - Parojčić, Jelena PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5072 AB - Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is classified as a class II model drug according to the Biopharmaceutical Classification System and exhibits prominent cohesiveness and low aqueous solubility (Choi et al., 2022). The aim of this work was to evaluate the influence of different directly compressible fillers/diluents on selected compact properties (namely, tensile strength, friability, and disintegration) and the dissolution of rivaroxaban from the prepared compacts. PB - Macedonian Pharmaceutical Association PB - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy C3 - Macedonian Pharmaceutical Bulletin T1 - The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban VL - 69 IS - Suppl 1 SP - 289 EP - 290 DO - 10.33320/maced.pharm.bull.2023.69.03.140 ER -
@conference{ author = "Vasiljević, Ivana and Pasik, Paulina and Turković, Erna and Ivković, Branka and Hejduk, Arkadiusz and Lulek, Janina and Parojčić, Jelena", year = "2023", abstract = "Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is classified as a class II model drug according to the Biopharmaceutical Classification System and exhibits prominent cohesiveness and low aqueous solubility (Choi et al., 2022). The aim of this work was to evaluate the influence of different directly compressible fillers/diluents on selected compact properties (namely, tensile strength, friability, and disintegration) and the dissolution of rivaroxaban from the prepared compacts.", publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy", journal = "Macedonian Pharmaceutical Bulletin", title = "The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban", volume = "69", number = "Suppl 1", pages = "289-290", doi = "10.33320/maced.pharm.bull.2023.69.03.140" }
Vasiljević, I., Pasik, P., Turković, E., Ivković, B., Hejduk, A., Lulek, J.,& Parojčić, J.. (2023). The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban. in Macedonian Pharmaceutical Bulletin Macedonian Pharmaceutical Association., 69(Suppl 1), 289-290. https://doi.org/10.33320/maced.pharm.bull.2023.69.03.140
Vasiljević I, Pasik P, Turković E, Ivković B, Hejduk A, Lulek J, Parojčić J. The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):289-290. doi:10.33320/maced.pharm.bull.2023.69.03.140 .
Vasiljević, Ivana, Pasik, Paulina, Turković, Erna, Ivković, Branka, Hejduk, Arkadiusz, Lulek, Janina, Parojčić, Jelena, "The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):289-290, https://doi.org/10.33320/maced.pharm.bull.2023.69.03.140 . .