Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients
Само за регистроване кориснике
2014
Аутори
Čabarkapa, AndreaŽivković, Lada
Zlatković-Švenda, Mirjana
Žukovec-Topalović, Dijana
Bajić, Vladan
Dekanski, Dragana
Borozan, Sunčica
Spremo-Potparević, Biljana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Increased oxidative stress caused by chronic inflammation is one of the underlying mechanisms in etiology of rheumatoid arthritis (RA). Reactive oxygen species produced during inflammatory response target cells DNA leading to important alterations. Novel therapeutic approaches in RA tend to combine the use of standard medications such as methotrexate with natural biologicaly active compounds, aimed to achive better antiinflamatory effect and improvement in clinical parameters, at the same time reducing medication-related side effects. Dry olive leaf extract (DOLE) is known for its antioxidant and anti-inflammatory properties, making it prospective for supplementation in RA. The aim of this study was to evaluate the ability of DOLE to protect against oxidative DNA damage in peripheral blood lymphocytes of chronic RA patients, by use of the comet assay. ...
Кључне речи:
Dry olive leaf extract / rheumatoid arthritis / DNA damageИзвор:
30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book, 2014, 19-19Издавач:
- Center for Molecular Medicine Cologne, University of Cologne
Финансирање / пројекти:
- Аберације ћелијског циклуса и утицај оксидативног стреса на неуродегенеративне процесе и малигну трансформацију ћелије (RS-MESTD-Basic Research (BR or ON)-173034)
Институција/група
PharmacyTY - CONF AU - Čabarkapa, Andrea AU - Živković, Lada AU - Zlatković-Švenda, Mirjana AU - Žukovec-Topalović, Dijana AU - Bajić, Vladan AU - Dekanski, Dragana AU - Borozan, Sunčica AU - Spremo-Potparević, Biljana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5131 AB - Increased oxidative stress caused by chronic inflammation is one of the underlying mechanisms in etiology of rheumatoid arthritis (RA). Reactive oxygen species produced during inflammatory response target cells DNA leading to important alterations. Novel therapeutic approaches in RA tend to combine the use of standard medications such as methotrexate with natural biologicaly active compounds, aimed to achive better antiinflamatory effect and improvement in clinical parameters, at the same time reducing medication-related side effects. Dry olive leaf extract (DOLE) is known for its antioxidant and anti-inflammatory properties, making it prospective for supplementation in RA. The aim of this study was to evaluate the ability of DOLE to protect against oxidative DNA damage in peripheral blood lymphocytes of chronic RA patients, by use of the comet assay. ... PB - Center for Molecular Medicine Cologne, University of Cologne C3 - 30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book T1 - Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients SP - 19 EP - 19 UR - https://hdl.handle.net/21.15107/rcub_farfar_5131 ER -
@conference{ author = "Čabarkapa, Andrea and Živković, Lada and Zlatković-Švenda, Mirjana and Žukovec-Topalović, Dijana and Bajić, Vladan and Dekanski, Dragana and Borozan, Sunčica and Spremo-Potparević, Biljana", year = "2014", abstract = "Increased oxidative stress caused by chronic inflammation is one of the underlying mechanisms in etiology of rheumatoid arthritis (RA). Reactive oxygen species produced during inflammatory response target cells DNA leading to important alterations. Novel therapeutic approaches in RA tend to combine the use of standard medications such as methotrexate with natural biologicaly active compounds, aimed to achive better antiinflamatory effect and improvement in clinical parameters, at the same time reducing medication-related side effects. Dry olive leaf extract (DOLE) is known for its antioxidant and anti-inflammatory properties, making it prospective for supplementation in RA. The aim of this study was to evaluate the ability of DOLE to protect against oxidative DNA damage in peripheral blood lymphocytes of chronic RA patients, by use of the comet assay. ...", publisher = "Center for Molecular Medicine Cologne, University of Cologne", journal = "30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book", title = "Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients", pages = "19-19", url = "https://hdl.handle.net/21.15107/rcub_farfar_5131" }
Čabarkapa, A., Živković, L., Zlatković-Švenda, M., Žukovec-Topalović, D., Bajić, V., Dekanski, D., Borozan, S.,& Spremo-Potparević, B.. (2014). Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients. in 30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book Center for Molecular Medicine Cologne, University of Cologne., 19-19. https://hdl.handle.net/21.15107/rcub_farfar_5131
Čabarkapa A, Živković L, Zlatković-Švenda M, Žukovec-Topalović D, Bajić V, Dekanski D, Borozan S, Spremo-Potparević B. Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients. in 30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book. 2014;:19-19. https://hdl.handle.net/21.15107/rcub_farfar_5131 .
Čabarkapa, Andrea, Živković, Lada, Zlatković-Švenda, Mirjana, Žukovec-Topalović, Dijana, Bajić, Vladan, Dekanski, Dragana, Borozan, Sunčica, Spremo-Potparević, Biljana, "Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients" in 30th Ernst Klenk Symposium in Molecular Medicine - DNA Damage Response and Repair Mechanisms in Aging and Disease, Sept. 21 – 23, 2014, Abstract Book (2014):19-19, https://hdl.handle.net/21.15107/rcub_farfar_5131 .