Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin
Аутори
Ušjak, DušanNovović, Katarina
Filipić, Brankica
Kojić, Milan
Filipović, Nenad
Stevanović, Magdalena M.
Arsenović-Ranin, Nevena
Milenković, Marina
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Colistin is used as a “last resort” drug in the treatment
of carbapenem-resistant Acinetobacter baumannii
infections. Though not the most convenient option due to
the serious side effects, this antibiotic can be very efficient
if administered properly (Garnacho-Montero and Timsit,
2019). However, for several years now, we are witnessing
a steady emergence of colistin-resistant (ColR) strains, with
the constant threat of a sudden burst worldwide (Nowak et
al., 2017). Having in mind that these strains are usually
non-susceptible to any of the existing treatments, i.e.
pandrug-resistant (PDR), the development of new
therapeutic strategies is desperately needed.
In the present study, we showed that colistin
susceptibility of ColR A. baumannii strains can be fully
restored in the presence of very low amounts of selenium
nanoparticles (SeNPs). To demonstrate potent synergistic
interactions between colistin and SeNPs, we performed
checkerboard and time-kill analyses.
Извор:
Macedonian Pharmaceutical Bulletin, 2022, 68, Suppl. 1, 295-296Издавач:
- Macedonian Pharmaceutical Association
Напомена:
- The Seventh Congress of Pharmacy in North Macedonia with International participation 2022,october 5-9, Ohrid
Институција/група
PharmacyTY - CONF AU - Ušjak, Dušan AU - Novović, Katarina AU - Filipić, Brankica AU - Kojić, Milan AU - Filipović, Nenad AU - Stevanović, Magdalena M. AU - Arsenović-Ranin, Nevena AU - Milenković, Marina PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5133 AB - Colistin is used as a “last resort” drug in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Though not the most convenient option due to the serious side effects, this antibiotic can be very efficient if administered properly (Garnacho-Montero and Timsit, 2019). However, for several years now, we are witnessing a steady emergence of colistin-resistant (ColR) strains, with the constant threat of a sudden burst worldwide (Nowak et al., 2017). Having in mind that these strains are usually non-susceptible to any of the existing treatments, i.e. pandrug-resistant (PDR), the development of new therapeutic strategies is desperately needed. In the present study, we showed that colistin susceptibility of ColR A. baumannii strains can be fully restored in the presence of very low amounts of selenium nanoparticles (SeNPs). To demonstrate potent synergistic interactions between colistin and SeNPs, we performed checkerboard and time-kill analyses. PB - Macedonian Pharmaceutical Association C3 - Macedonian Pharmaceutical Bulletin T1 - Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin VL - 68 IS - Suppl. 1 SP - 295 EP - 296 DO - 10.33320/maced.pharm.bull.2022.68.03.142 ER -
@conference{ author = "Ušjak, Dušan and Novović, Katarina and Filipić, Brankica and Kojić, Milan and Filipović, Nenad and Stevanović, Magdalena M. and Arsenović-Ranin, Nevena and Milenković, Marina", year = "2022", abstract = "Colistin is used as a “last resort” drug in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Though not the most convenient option due to the serious side effects, this antibiotic can be very efficient if administered properly (Garnacho-Montero and Timsit, 2019). However, for several years now, we are witnessing a steady emergence of colistin-resistant (ColR) strains, with the constant threat of a sudden burst worldwide (Nowak et al., 2017). Having in mind that these strains are usually non-susceptible to any of the existing treatments, i.e. pandrug-resistant (PDR), the development of new therapeutic strategies is desperately needed. In the present study, we showed that colistin susceptibility of ColR A. baumannii strains can be fully restored in the presence of very low amounts of selenium nanoparticles (SeNPs). To demonstrate potent synergistic interactions between colistin and SeNPs, we performed checkerboard and time-kill analyses.", publisher = "Macedonian Pharmaceutical Association", journal = "Macedonian Pharmaceutical Bulletin", title = "Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin", volume = "68", number = "Suppl. 1", pages = "295-296", doi = "10.33320/maced.pharm.bull.2022.68.03.142" }
Ušjak, D., Novović, K., Filipić, B., Kojić, M., Filipović, N., Stevanović, M. M., Arsenović-Ranin, N.,& Milenković, M.. (2022). Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin. in Macedonian Pharmaceutical Bulletin Macedonian Pharmaceutical Association., 68(Suppl. 1), 295-296. https://doi.org/10.33320/maced.pharm.bull.2022.68.03.142
Ušjak D, Novović K, Filipić B, Kojić M, Filipović N, Stevanović MM, Arsenović-Ranin N, Milenković M. Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin. in Macedonian Pharmaceutical Bulletin. 2022;68(Suppl. 1):295-296. doi:10.33320/maced.pharm.bull.2022.68.03.142 .
Ušjak, Dušan, Novović, Katarina, Filipić, Brankica, Kojić, Milan, Filipović, Nenad, Stevanović, Magdalena M., Arsenović-Ranin, Nevena, Milenković, Marina, "Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin" in Macedonian Pharmaceutical Bulletin, 68, no. Suppl. 1 (2022):295-296, https://doi.org/10.33320/maced.pharm.bull.2022.68.03.142 . .