Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase
Апстракт
Investigation of the retention behavior of a wide range of analytes (43 nitrogen containing heterocyclic
and guanidine derivatives such, as imidazoline and serotonin receptor ligands, or their related
compounds) was performed on the mixed-mode stationary phase in the combined
reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. The imidazoline
receptor ligands are the imidazoline or guanidine analogues with numerous therapeutic applications
(such, as antihypertensives, diuretics, antiallergenics, antidiabetics, and antipsychotics), while the
serotonin receptor ligands are the piperazine derivatives which exert an effect on positive and negative
symptoms of schizophrenia, mania and mixed states of bipolar disorder.
On the mixed-mode stationary phase, the retention behaviour of investigated compounds
was described as a function of the aqueous eluent volume fractions, φ(aq), and total polarity of mobile
phase (Ptot). The turning point was discusse...d based on different mobile phase characteristics
representing the shift between the HILIC and the RP chromatographic mode. The influence
of molecular properties on the main retention characteristics (turining point and the extrapolated
retention parameters) is going to be discussed.
Извор:
42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts, 2019Издавач:
- Institute of Chemistry University of Silesia in Katowice
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
Напомена:
- The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds, June 4-7, 2019, Szczyrk, Poland
Институција/група
PharmacyTY - CONF AU - Obradović, Darija AU - Oljačić, Slavica AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5156 AB - Investigation of the retention behavior of a wide range of analytes (43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands, or their related compounds) was performed on the mixed-mode stationary phase in the combined reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. The imidazoline receptor ligands are the imidazoline or guanidine analogues with numerous therapeutic applications (such, as antihypertensives, diuretics, antiallergenics, antidiabetics, and antipsychotics), while the serotonin receptor ligands are the piperazine derivatives which exert an effect on positive and negative symptoms of schizophrenia, mania and mixed states of bipolar disorder. On the mixed-mode stationary phase, the retention behaviour of investigated compounds was described as a function of the aqueous eluent volume fractions, φ(aq), and total polarity of mobile phase (Ptot). The turning point was discussed based on different mobile phase characteristics representing the shift between the HILIC and the RP chromatographic mode. The influence of molecular properties on the main retention characteristics (turining point and the extrapolated retention parameters) is going to be discussed. PB - Institute of Chemistry University of Silesia in Katowice C3 - 42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts T1 - Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase UR - https://hdl.handle.net/21.15107/rcub_farfar_5156 ER -
@conference{ author = "Obradović, Darija and Oljačić, Slavica and Nikolić, Katarina and Agbaba, Danica", year = "2019", abstract = "Investigation of the retention behavior of a wide range of analytes (43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands, or their related compounds) was performed on the mixed-mode stationary phase in the combined reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. The imidazoline receptor ligands are the imidazoline or guanidine analogues with numerous therapeutic applications (such, as antihypertensives, diuretics, antiallergenics, antidiabetics, and antipsychotics), while the serotonin receptor ligands are the piperazine derivatives which exert an effect on positive and negative symptoms of schizophrenia, mania and mixed states of bipolar disorder. On the mixed-mode stationary phase, the retention behaviour of investigated compounds was described as a function of the aqueous eluent volume fractions, φ(aq), and total polarity of mobile phase (Ptot). The turning point was discussed based on different mobile phase characteristics representing the shift between the HILIC and the RP chromatographic mode. The influence of molecular properties on the main retention characteristics (turining point and the extrapolated retention parameters) is going to be discussed.", publisher = "Institute of Chemistry University of Silesia in Katowice", journal = "42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts", title = "Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase", url = "https://hdl.handle.net/21.15107/rcub_farfar_5156" }
Obradović, D., Oljačić, S., Nikolić, K.,& Agbaba, D.. (2019). Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase. in 42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts Institute of Chemistry University of Silesia in Katowice.. https://hdl.handle.net/21.15107/rcub_farfar_5156
Obradović D, Oljačić S, Nikolić K, Agbaba D. Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase. in 42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts. 2019;. https://hdl.handle.net/21.15107/rcub_farfar_5156 .
Obradović, Darija, Oljačić, Slavica, Nikolić, Katarina, Agbaba, Danica, "Investigation and prediction of retention characteristics of selected set of central nervous system active compounds on mixed-mode diol stationary phase" in 42nd Symposium Chromatographic Methods of Investigating Organic Compounds, Book of Abstracts (2019), https://hdl.handle.net/21.15107/rcub_farfar_5156 .