Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease
Само за регистроване кориснике
2023
Аутори
Džoljić, EleonoraSarić-Matutinović, Marija
Stojković, Oliver
Veličković, Jelena
Milinković, Neda
Kostić, Vladimir
Ignjatović, Svetlana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (...2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD.
Кључне речи:
Parkinson's disease / 25(OH)-vitamin D / vitamin D / vitamin D deficiencyИзвор:
Neuroscience, 2023, 533, 53-62Издавач:
- Elsevier Ltd
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.neuroscience.2023.10.004
ISSN: 0306-4522
PubMed: 37832907
Scopus: 2-s2.0-85174537476
Институција/група
PharmacyTY - JOUR AU - Džoljić, Eleonora AU - Sarić-Matutinović, Marija AU - Stojković, Oliver AU - Veličković, Jelena AU - Milinković, Neda AU - Kostić, Vladimir AU - Ignjatović, Svetlana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5179 AB - Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD. PB - Elsevier Ltd T2 - Neuroscience T1 - Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease VL - 533 SP - 53 EP - 62 DO - 10.1016/j.neuroscience.2023.10.004 ER -
@article{ author = "Džoljić, Eleonora and Sarić-Matutinović, Marija and Stojković, Oliver and Veličković, Jelena and Milinković, Neda and Kostić, Vladimir and Ignjatović, Svetlana", year = "2023", abstract = "Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods: Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results: Higher frequency of vitamin D deficiency (<50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P = 0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206–4.298; P < 0.011). Significantly higher UPDRS (35.85 ± 1.35 and 32.09 ± 0.99, respectively, P = 0.023) and HY scores (2(1.5–2.5) and 1.5(1.0–2.0), respectively, P = 0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P > 0.05). Conclusions: Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD.", publisher = "Elsevier Ltd", journal = "Neuroscience", title = "Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease", volume = "533", pages = "53-62", doi = "10.1016/j.neuroscience.2023.10.004" }
Džoljić, E., Sarić-Matutinović, M., Stojković, O., Veličković, J., Milinković, N., Kostić, V.,& Ignjatović, S.. (2023). Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease. in Neuroscience Elsevier Ltd., 533, 53-62. https://doi.org/10.1016/j.neuroscience.2023.10.004
Džoljić E, Sarić-Matutinović M, Stojković O, Veličković J, Milinković N, Kostić V, Ignjatović S. Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease. in Neuroscience. 2023;533:53-62. doi:10.1016/j.neuroscience.2023.10.004 .
Džoljić, Eleonora, Sarić-Matutinović, Marija, Stojković, Oliver, Veličković, Jelena, Milinković, Neda, Kostić, Vladimir, Ignjatović, Svetlana, "Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease" in Neuroscience, 533 (2023):53-62, https://doi.org/10.1016/j.neuroscience.2023.10.004 . .
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