The ionization of fluoroquinolones in the presence of differently charged surfactants
Апстракт
The pKa values of ciprofloxacin (CPF) and norfloxacin (NRF) were
determined potentiometrically, with and without the presence of differently
charged micelles, as biomembrane mimetic models. The shift in protolytic
equilibria are observed in the presence of surfactants, SDS (ΔpKa1 = +2.02;
ΔpKa2 = +0.57); CTAB (ΔpKa1 = -0.09; ΔpKa2 = -0.23) and TX-100 (ΔpKa1 =
+0.24; ΔpKa2 = +0.29). The change in distribution of equilibrium forms is
most expressed in pH range 6 – 8 which may indicate on potential interactions
with molecules of different polarity and charge under physiological
conditions.
Извор:
Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2018, II, 967-970Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
Напомена:
- 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 24-28, 2018 Belgrade, Serbia
Институција/група
PharmacyTY - CONF AU - Popović-Nikolić, Marija AU - Popović, Gordana AU - Berdon, Katarina PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5183 AB - The pKa values of ciprofloxacin (CPF) and norfloxacin (NRF) were determined potentiometrically, with and without the presence of differently charged micelles, as biomembrane mimetic models. The shift in protolytic equilibria are observed in the presence of surfactants, SDS (ΔpKa1 = +2.02; ΔpKa2 = +0.57); CTAB (ΔpKa1 = -0.09; ΔpKa2 = -0.23) and TX-100 (ΔpKa1 = +0.24; ΔpKa2 = +0.29). The change in distribution of equilibrium forms is most expressed in pH range 6 – 8 which may indicate on potential interactions with molecules of different polarity and charge under physiological conditions. PB - Society of Physical Chemists of Serbia C3 - Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry T1 - The ionization of fluoroquinolones in the presence of differently charged surfactants VL - II SP - 967 EP - 970 UR - https://hdl.handle.net/21.15107/rcub_farfar_5183 ER -
@conference{ author = "Popović-Nikolić, Marija and Popović, Gordana and Berdon, Katarina", year = "2018", abstract = "The pKa values of ciprofloxacin (CPF) and norfloxacin (NRF) were determined potentiometrically, with and without the presence of differently charged micelles, as biomembrane mimetic models. The shift in protolytic equilibria are observed in the presence of surfactants, SDS (ΔpKa1 = +2.02; ΔpKa2 = +0.57); CTAB (ΔpKa1 = -0.09; ΔpKa2 = -0.23) and TX-100 (ΔpKa1 = +0.24; ΔpKa2 = +0.29). The change in distribution of equilibrium forms is most expressed in pH range 6 – 8 which may indicate on potential interactions with molecules of different polarity and charge under physiological conditions.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry", title = "The ionization of fluoroquinolones in the presence of differently charged surfactants", volume = "II", pages = "967-970", url = "https://hdl.handle.net/21.15107/rcub_farfar_5183" }
Popović-Nikolić, M., Popović, G.,& Berdon, K.. (2018). The ionization of fluoroquinolones in the presence of differently charged surfactants. in Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry Society of Physical Chemists of Serbia., II, 967-970. https://hdl.handle.net/21.15107/rcub_farfar_5183
Popović-Nikolić M, Popović G, Berdon K. The ionization of fluoroquinolones in the presence of differently charged surfactants. in Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2018;II:967-970. https://hdl.handle.net/21.15107/rcub_farfar_5183 .
Popović-Nikolić, Marija, Popović, Gordana, Berdon, Katarina, "The ionization of fluoroquinolones in the presence of differently charged surfactants" in Physical Chemistry 2018 (Proceedings) 14th International Conference on Fundamental and Applied Aspects of Physical Chemistry, II (2018):967-970, https://hdl.handle.net/21.15107/rcub_farfar_5183 .