Olive leaf, DNA damage and chelation therapy
Само за регистроване кориснике
2021
Аутори
Čabarkapa-Pirković, AndreaŽivković, Lada
Dekanski, Dragana
Topalović, Dijana
Spremo-Potparević, Biljana
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Olive leaf (OL) is a precious source of bioactive compounds for versatile biomedical applications. Oleuropein, the main constituent from olive leaves, and its metabolite hydroxytyrosol are responsible for the majority of the observed biological effects. However, joined components of OL achieved better biological effects than its isolated individual constituents, indicating their synergistic effect. Predominantly free radical scavenging and metal chelation properties of OL compounds are responsible for the protective effects against oxidative damage and could be endorsed for its antioxidant and antigenotoxic effects. Local environment in cells such as the presence of transition metals, oxygen radicals, change in pH value, and the concentration of the flavonoid compounds can modify their activity from antioxidant to prooxidant and from antigenotoxic to genotoxic. Effects of complexes formed between flavonoids, metals, and DNA molecule, in heavy metal intoxicated individuals that are trea...ted with ethylenediaminetetraacetic acid chelation therapy, require further research attention considering the demonstrated prooxidant and genotoxic effects.
Кључне речи:
olive leaf / DNA damage / chelation therapyИзвор:
Olives and Olive Oil in Health and Disease Prevention, 2021, 457-469Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/B978-0-12-819528-4.00021-3
ISBN: 978-0-12-819528-4
Scopus: 2-s2.0-85125967548
Институција/група
PharmacyTY - CHAP AU - Čabarkapa-Pirković, Andrea AU - Živković, Lada AU - Dekanski, Dragana AU - Topalović, Dijana AU - Spremo-Potparević, Biljana PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5184 AB - Olive leaf (OL) is a precious source of bioactive compounds for versatile biomedical applications. Oleuropein, the main constituent from olive leaves, and its metabolite hydroxytyrosol are responsible for the majority of the observed biological effects. However, joined components of OL achieved better biological effects than its isolated individual constituents, indicating their synergistic effect. Predominantly free radical scavenging and metal chelation properties of OL compounds are responsible for the protective effects against oxidative damage and could be endorsed for its antioxidant and antigenotoxic effects. Local environment in cells such as the presence of transition metals, oxygen radicals, change in pH value, and the concentration of the flavonoid compounds can modify their activity from antioxidant to prooxidant and from antigenotoxic to genotoxic. Effects of complexes formed between flavonoids, metals, and DNA molecule, in heavy metal intoxicated individuals that are treated with ethylenediaminetetraacetic acid chelation therapy, require further research attention considering the demonstrated prooxidant and genotoxic effects. PB - Elsevier T2 - Olives and Olive Oil in Health and Disease Prevention T1 - Olive leaf, DNA damage and chelation therapy SP - 457 EP - 469 DO - 10.1016/B978-0-12-819528-4.00021-3 ER -
@inbook{ author = "Čabarkapa-Pirković, Andrea and Živković, Lada and Dekanski, Dragana and Topalović, Dijana and Spremo-Potparević, Biljana", year = "2021", abstract = "Olive leaf (OL) is a precious source of bioactive compounds for versatile biomedical applications. Oleuropein, the main constituent from olive leaves, and its metabolite hydroxytyrosol are responsible for the majority of the observed biological effects. However, joined components of OL achieved better biological effects than its isolated individual constituents, indicating their synergistic effect. Predominantly free radical scavenging and metal chelation properties of OL compounds are responsible for the protective effects against oxidative damage and could be endorsed for its antioxidant and antigenotoxic effects. Local environment in cells such as the presence of transition metals, oxygen radicals, change in pH value, and the concentration of the flavonoid compounds can modify their activity from antioxidant to prooxidant and from antigenotoxic to genotoxic. Effects of complexes formed between flavonoids, metals, and DNA molecule, in heavy metal intoxicated individuals that are treated with ethylenediaminetetraacetic acid chelation therapy, require further research attention considering the demonstrated prooxidant and genotoxic effects.", publisher = "Elsevier", journal = "Olives and Olive Oil in Health and Disease Prevention", booktitle = "Olive leaf, DNA damage and chelation therapy", pages = "457-469", doi = "10.1016/B978-0-12-819528-4.00021-3" }
Čabarkapa-Pirković, A., Živković, L., Dekanski, D., Topalović, D.,& Spremo-Potparević, B.. (2021). Olive leaf, DNA damage and chelation therapy. in Olives and Olive Oil in Health and Disease Prevention Elsevier., 457-469. https://doi.org/10.1016/B978-0-12-819528-4.00021-3
Čabarkapa-Pirković A, Živković L, Dekanski D, Topalović D, Spremo-Potparević B. Olive leaf, DNA damage and chelation therapy. in Olives and Olive Oil in Health and Disease Prevention. 2021;:457-469. doi:10.1016/B978-0-12-819528-4.00021-3 .
Čabarkapa-Pirković, Andrea, Živković, Lada, Dekanski, Dragana, Topalović, Dijana, Spremo-Potparević, Biljana, "Olive leaf, DNA damage and chelation therapy" in Olives and Olive Oil in Health and Disease Prevention (2021):457-469, https://doi.org/10.1016/B978-0-12-819528-4.00021-3 . .