Evaluation of the antioxidant potential of Biochaga in vitro
Апстракт
Background: Antioxidants and prooxidants have an impact on the intracellular oxidative equilibrium. Overproduction of prooxidants leads to oxidative stress caused by imbalances in oxidative reduction pathways. The body can be supplied with non-enzymatic, low molecular weight antioxidants through diet.The edible medicinal mushroom Chaga, Inonotus obliquus (Ach. ex Pers.) Pilat, has long been long used to treat or prevent various health conditions and disorders. The bioactive compounds of Chaga exhibit antitumor, anti-inflammatory, hypoglycemic, immunomodulatory, antioxidant, and antigenotoxic effects. Material and Methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, FRAP (ferric reducing antioxidant power) total antioxidant activity, and hydroxyl radical scavenging capacity were measured.
Results: Commercial Biochaga (B), a water extract of Biochaga mushroom, was obtained from Sibpribor Ooo, Irkutsk, Russia. B (IC =5.9 mg/ mL) showed moderate reducing power compared in co...mparison to vitamin C and strong compared to BTH. B (IC =1.78 mg/mL) showed remarkable free radical scavenging and moderate hydroxyl scavenging activity (IC =8.473 mg/mL). Conclusion: We can place Biochaga in the radical scavenging category because it efficiently eliminates hydroxyl radicals against which the body has insufficient antioxidant defenses.
Кључне речи:
Biochaga / DNA damage / comet assay / antioxidantИзвор:
Balkan Journal of Medical Genetics, Supplement 1 (Abstract book), 2023, 26, 146-146Издавач:
- Macedonian Academy of Sciences and Arts
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Напомена:
- 14th Balkan Congress of Human Genetics and 9 th Rare Disease SEE Meeting “Genetic Diseases from Diagnostics to Prevention and Therapy”(ABSTRACT BOOK), October 05-07, 2023, Hotel “DoubleTree by Hilton” Skopje, North Macedonia
Институција/група
PharmacyTY - CONF AU - Živković, Lada AU - Topalović, Dijana AU - Bajić, Vladan AU - Spremo-Potparević, Biljana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5185 AB - Background: Antioxidants and prooxidants have an impact on the intracellular oxidative equilibrium. Overproduction of prooxidants leads to oxidative stress caused by imbalances in oxidative reduction pathways. The body can be supplied with non-enzymatic, low molecular weight antioxidants through diet.The edible medicinal mushroom Chaga, Inonotus obliquus (Ach. ex Pers.) Pilat, has long been long used to treat or prevent various health conditions and disorders. The bioactive compounds of Chaga exhibit antitumor, anti-inflammatory, hypoglycemic, immunomodulatory, antioxidant, and antigenotoxic effects. Material and Methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, FRAP (ferric reducing antioxidant power) total antioxidant activity, and hydroxyl radical scavenging capacity were measured. Results: Commercial Biochaga (B), a water extract of Biochaga mushroom, was obtained from Sibpribor Ooo, Irkutsk, Russia. B (IC =5.9 mg/ mL) showed moderate reducing power compared in comparison to vitamin C and strong compared to BTH. B (IC =1.78 mg/mL) showed remarkable free radical scavenging and moderate hydroxyl scavenging activity (IC =8.473 mg/mL). Conclusion: We can place Biochaga in the radical scavenging category because it efficiently eliminates hydroxyl radicals against which the body has insufficient antioxidant defenses. PB - Macedonian Academy of Sciences and Arts C3 - Balkan Journal of Medical Genetics, Supplement 1 (Abstract book) T1 - Evaluation of the antioxidant potential of Biochaga in vitro VL - 26 SP - 146 EP - 146 UR - https://hdl.handle.net/21.15107/rcub_farfar_5185 ER -
@conference{ author = "Živković, Lada and Topalović, Dijana and Bajić, Vladan and Spremo-Potparević, Biljana", year = "2023", abstract = "Background: Antioxidants and prooxidants have an impact on the intracellular oxidative equilibrium. Overproduction of prooxidants leads to oxidative stress caused by imbalances in oxidative reduction pathways. The body can be supplied with non-enzymatic, low molecular weight antioxidants through diet.The edible medicinal mushroom Chaga, Inonotus obliquus (Ach. ex Pers.) Pilat, has long been long used to treat or prevent various health conditions and disorders. The bioactive compounds of Chaga exhibit antitumor, anti-inflammatory, hypoglycemic, immunomodulatory, antioxidant, and antigenotoxic effects. Material and Methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, FRAP (ferric reducing antioxidant power) total antioxidant activity, and hydroxyl radical scavenging capacity were measured. Results: Commercial Biochaga (B), a water extract of Biochaga mushroom, was obtained from Sibpribor Ooo, Irkutsk, Russia. B (IC =5.9 mg/ mL) showed moderate reducing power compared in comparison to vitamin C and strong compared to BTH. B (IC =1.78 mg/mL) showed remarkable free radical scavenging and moderate hydroxyl scavenging activity (IC =8.473 mg/mL). Conclusion: We can place Biochaga in the radical scavenging category because it efficiently eliminates hydroxyl radicals against which the body has insufficient antioxidant defenses.", publisher = "Macedonian Academy of Sciences and Arts", journal = "Balkan Journal of Medical Genetics, Supplement 1 (Abstract book)", title = "Evaluation of the antioxidant potential of Biochaga in vitro", volume = "26", pages = "146-146", url = "https://hdl.handle.net/21.15107/rcub_farfar_5185" }
Živković, L., Topalović, D., Bajić, V.,& Spremo-Potparević, B.. (2023). Evaluation of the antioxidant potential of Biochaga in vitro. in Balkan Journal of Medical Genetics, Supplement 1 (Abstract book) Macedonian Academy of Sciences and Arts., 26, 146-146. https://hdl.handle.net/21.15107/rcub_farfar_5185
Živković L, Topalović D, Bajić V, Spremo-Potparević B. Evaluation of the antioxidant potential of Biochaga in vitro. in Balkan Journal of Medical Genetics, Supplement 1 (Abstract book). 2023;26:146-146. https://hdl.handle.net/21.15107/rcub_farfar_5185 .
Živković, Lada, Topalović, Dijana, Bajić, Vladan, Spremo-Potparević, Biljana, "Evaluation of the antioxidant potential of Biochaga in vitro" in Balkan Journal of Medical Genetics, Supplement 1 (Abstract book), 26 (2023):146-146, https://hdl.handle.net/21.15107/rcub_farfar_5185 .