Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents
Само за регистроване кориснике
2021
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The plants of genus Cymbopogon (family Poaceae) are well known for their use in traditional medicine and for the high content of essential oils that are widely used as flavoring agents, fragrances, cosmetics, and pharmaceuticals. Essential oils isolated from the inflorescences of Cymbopogon nervatus (Hochst.) Chiov. and C. schoenanthus (L.) Spreng. from Sudan were studied. GC-FID/MS analysis showed that C. nervatus essential oils is characterized by the high content of p-menthadienols (64.0-76.2%), whereas oils of C. schoenanthus are rich in monoterpene piperitone (47.7-58.7%). The oils were tested for spasmolytic activity on isolated rat ileum, using three different experimental models: against spontaneous contractions, contractions induced with acetylcholine and contractions induced with potassium chloride. The essential oils of both species exhibited strong, significant and dose-dependent spasmolytic activity. In addition, essential oils were investigated for antimicrobial activity ...by the microdilution method. Both oils were active against the strains of Staphylococcus aureus (MICs 0.85-1.3 mg/ml), Staphylococcus epidermidis (MICs 0.78-1.3 mg/ml) and Candida albicans (MICs 0.63-1.3 mg/ml), whereas Gram (-) bacteria (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) were resistant. The observed spasmolytic effect of the inflorescence essential oils of C. nervatus and C. schoenanthus emphasizes its beneficial properties and is in agreement with their traditional use, especially for gastrointestinal ailments.
Кључне речи:
Cymbopogon schoenathus / Cymbopogon nervatus / spasmolytic activity / isolated rat ileumИзвор:
International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual, 2021Напомена:
- International Conference on Traditional Medicine and Phytochemistry, TMED 2021/Virtual, July 12-14, 2021
- Predavanje po pozivu sa međunarodnog skupa, kategorija M32
Институција/група
PharmacyTY - CONF AU - Drobac, Milica AU - Omar, Eihab AU - Kovačević, Nada PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5245 AB - The plants of genus Cymbopogon (family Poaceae) are well known for their use in traditional medicine and for the high content of essential oils that are widely used as flavoring agents, fragrances, cosmetics, and pharmaceuticals. Essential oils isolated from the inflorescences of Cymbopogon nervatus (Hochst.) Chiov. and C. schoenanthus (L.) Spreng. from Sudan were studied. GC-FID/MS analysis showed that C. nervatus essential oils is characterized by the high content of p-menthadienols (64.0-76.2%), whereas oils of C. schoenanthus are rich in monoterpene piperitone (47.7-58.7%). The oils were tested for spasmolytic activity on isolated rat ileum, using three different experimental models: against spontaneous contractions, contractions induced with acetylcholine and contractions induced with potassium chloride. The essential oils of both species exhibited strong, significant and dose-dependent spasmolytic activity. In addition, essential oils were investigated for antimicrobial activity by the microdilution method. Both oils were active against the strains of Staphylococcus aureus (MICs 0.85-1.3 mg/ml), Staphylococcus epidermidis (MICs 0.78-1.3 mg/ml) and Candida albicans (MICs 0.63-1.3 mg/ml), whereas Gram (-) bacteria (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) were resistant. The observed spasmolytic effect of the inflorescence essential oils of C. nervatus and C. schoenanthus emphasizes its beneficial properties and is in agreement with their traditional use, especially for gastrointestinal ailments. C3 - International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual T1 - Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents UR - https://hdl.handle.net/21.15107/rcub_farfar_5245 ER -
@conference{ author = "Drobac, Milica and Omar, Eihab and Kovačević, Nada", year = "2021", abstract = "The plants of genus Cymbopogon (family Poaceae) are well known for their use in traditional medicine and for the high content of essential oils that are widely used as flavoring agents, fragrances, cosmetics, and pharmaceuticals. Essential oils isolated from the inflorescences of Cymbopogon nervatus (Hochst.) Chiov. and C. schoenanthus (L.) Spreng. from Sudan were studied. GC-FID/MS analysis showed that C. nervatus essential oils is characterized by the high content of p-menthadienols (64.0-76.2%), whereas oils of C. schoenanthus are rich in monoterpene piperitone (47.7-58.7%). The oils were tested for spasmolytic activity on isolated rat ileum, using three different experimental models: against spontaneous contractions, contractions induced with acetylcholine and contractions induced with potassium chloride. The essential oils of both species exhibited strong, significant and dose-dependent spasmolytic activity. In addition, essential oils were investigated for antimicrobial activity by the microdilution method. Both oils were active against the strains of Staphylococcus aureus (MICs 0.85-1.3 mg/ml), Staphylococcus epidermidis (MICs 0.78-1.3 mg/ml) and Candida albicans (MICs 0.63-1.3 mg/ml), whereas Gram (-) bacteria (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) were resistant. The observed spasmolytic effect of the inflorescence essential oils of C. nervatus and C. schoenanthus emphasizes its beneficial properties and is in agreement with their traditional use, especially for gastrointestinal ailments.", journal = "International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual", title = "Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents", url = "https://hdl.handle.net/21.15107/rcub_farfar_5245" }
Drobac, M., Omar, E.,& Kovačević, N.. (2021). Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents. in International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual. https://hdl.handle.net/21.15107/rcub_farfar_5245
Drobac M, Omar E, Kovačević N. Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents. in International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual. 2021;. https://hdl.handle.net/21.15107/rcub_farfar_5245 .
Drobac, Milica, Omar, Eihab, Kovačević, Nada, "Essential oils of Cymbopogon Spreng. species - potential spasmolytic agents" in International Conference on Traditional Medicine and Phytochemistry - TMED 2021/Virtual (2021), https://hdl.handle.net/21.15107/rcub_farfar_5245 .