Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals
Само за регистроване кориснике
2004
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.
Кључне речи:
planar chromatography / omeprazole / pantoprazole / impurities / pharmaceutical preparationsИзвор:
Journal of Planar Chromatography - Modern TLC, 2004, 17, 3, 169-172Издавач:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.17.2004.3.2
ISSN: 0933-4173
WoS: 000222956100002
Scopus: 2-s2.0-4043090664
Институција/група
PharmacyTY - JOUR AU - Agbaba, Danica AU - Novović, D AU - Karljiković-Rajić, Katarina AU - Marinković, Valentina PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/525 AB - A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography - Modern TLC T1 - Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals VL - 17 IS - 3 SP - 169 EP - 172 DO - 10.1556/JPC.17.2004.3.2 ER -
@article{ author = "Agbaba, Danica and Novović, D and Karljiković-Rajić, Katarina and Marinković, Valentina", year = "2004", abstract = "A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography - Modern TLC", title = "Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals", volume = "17", number = "3", pages = "169-172", doi = "10.1556/JPC.17.2004.3.2" }
Agbaba, D., Novović, D., Karljiković-Rajić, K.,& Marinković, V.. (2004). Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals. in Journal of Planar Chromatography - Modern TLC Research Inst Medicinal Plants, Budakalasz., 17(3), 169-172. https://doi.org/10.1556/JPC.17.2004.3.2
Agbaba D, Novović D, Karljiković-Rajić K, Marinković V. Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals. in Journal of Planar Chromatography - Modern TLC. 2004;17(3):169-172. doi:10.1556/JPC.17.2004.3.2 .
Agbaba, Danica, Novović, D, Karljiković-Rajić, Katarina, Marinković, Valentina, "Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals" in Journal of Planar Chromatography - Modern TLC, 17, no. 3 (2004):169-172, https://doi.org/10.1556/JPC.17.2004.3.2 . .