Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)
Апстракт
Recent studies demonstrated that Rumex species exhibit various
pharmacological activities, such as antiinflamatory, antioxidant, anticancer,
antimicrobial, but there are almost no data on pharmacological activities of Balcan
endemic species Rumex balcanicus. Thus, the aim was to examine antioxidant
activity, using DPPH and FRAP method, antimicrobial activity via broth
microdilution method and α-amylase inhibitory activity using DNS reagent of
aqueous and methanol extracts of roots and aerial parts of R. balcanicus, collected on
Vlasina Lake in 2014. All tested extracts exhibited high antioxidant activity which
has been correlated with the high content of polyphenols. Aqueous extracts exhibited
lower activity compared to methanol extracts. Methanol extract ofR. balcanicus roots
showed the highest activity, both in DPPH (IC50= 9.57 μg/mL) and FRAP test
(IC50=3.98 μmol Fe/mg of extract), while aqueous extract of aerial parts showed the
lowest activity (IC50= 24.73 μg/mL; IC50=...2.11 μmol Fe/mg). Only methanol extract
of aerial parts showed α-amylase inhibitory activity with IC50=252 μg/mL. All
extracts had low antimicrobial activity against almost all tested bacterial strains except
against Bacillus subtilis. Positive results obtained in this study show that R. balcanisus
contains potential as a new raw material and for the development of drugs efficient in
treating diabetes.
Кључне речи:
Rumex balcanicus / DPPH / FRAP / enzyme inhibition / antimicrobial activityИзвор:
13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts, 2019, 159-159Издавач:
- Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
- Institute for Nature Conservation of Serbia
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
- Биљни и синтетички биоактивни производи новије генерације (RS-MESTD-Technological Development (TD or TR)-34012)
Напомена:
- 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, Stara planina Mt., 20th to 23th June 2019
Институција/група
PharmacyTY - CONF AU - Radović, Jelena AU - Milenković, Marina AU - Ranđelović, Vladimir AU - Kundaković-Vasović, Tatjana PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5295 AB - Recent studies demonstrated that Rumex species exhibit various pharmacological activities, such as antiinflamatory, antioxidant, anticancer, antimicrobial, but there are almost no data on pharmacological activities of Balcan endemic species Rumex balcanicus. Thus, the aim was to examine antioxidant activity, using DPPH and FRAP method, antimicrobial activity via broth microdilution method and α-amylase inhibitory activity using DNS reagent of aqueous and methanol extracts of roots and aerial parts of R. balcanicus, collected on Vlasina Lake in 2014. All tested extracts exhibited high antioxidant activity which has been correlated with the high content of polyphenols. Aqueous extracts exhibited lower activity compared to methanol extracts. Methanol extract ofR. balcanicus roots showed the highest activity, both in DPPH (IC50= 9.57 μg/mL) and FRAP test (IC50=3.98 μmol Fe/mg of extract), while aqueous extract of aerial parts showed the lowest activity (IC50= 24.73 μg/mL; IC50=2.11 μmol Fe/mg). Only methanol extract of aerial parts showed α-amylase inhibitory activity with IC50=252 μg/mL. All extracts had low antimicrobial activity against almost all tested bacterial strains except against Bacillus subtilis. Positive results obtained in this study show that R. balcanisus contains potential as a new raw material and for the development of drugs efficient in treating diabetes. PB - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš PB - Institute for Nature Conservation of Serbia C3 - 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts T1 - Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae) SP - 159 EP - 159 UR - https://hdl.handle.net/21.15107/rcub_farfar_5295 ER -
@conference{ author = "Radović, Jelena and Milenković, Marina and Ranđelović, Vladimir and Kundaković-Vasović, Tatjana", year = "2019", abstract = "Recent studies demonstrated that Rumex species exhibit various pharmacological activities, such as antiinflamatory, antioxidant, anticancer, antimicrobial, but there are almost no data on pharmacological activities of Balcan endemic species Rumex balcanicus. Thus, the aim was to examine antioxidant activity, using DPPH and FRAP method, antimicrobial activity via broth microdilution method and α-amylase inhibitory activity using DNS reagent of aqueous and methanol extracts of roots and aerial parts of R. balcanicus, collected on Vlasina Lake in 2014. All tested extracts exhibited high antioxidant activity which has been correlated with the high content of polyphenols. Aqueous extracts exhibited lower activity compared to methanol extracts. Methanol extract ofR. balcanicus roots showed the highest activity, both in DPPH (IC50= 9.57 μg/mL) and FRAP test (IC50=3.98 μmol Fe/mg of extract), while aqueous extract of aerial parts showed the lowest activity (IC50= 24.73 μg/mL; IC50=2.11 μmol Fe/mg). Only methanol extract of aerial parts showed α-amylase inhibitory activity with IC50=252 μg/mL. All extracts had low antimicrobial activity against almost all tested bacterial strains except against Bacillus subtilis. Positive results obtained in this study show that R. balcanisus contains potential as a new raw material and for the development of drugs efficient in treating diabetes.", publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia", journal = "13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts", title = "Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)", pages = "159-159", url = "https://hdl.handle.net/21.15107/rcub_farfar_5295" }
Radović, J., Milenković, M., Ranđelović, V.,& Kundaković-Vasović, T.. (2019). Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 159-159. https://hdl.handle.net/21.15107/rcub_farfar_5295
Radović J, Milenković M, Ranđelović V, Kundaković-Vasović T. Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts. 2019;:159-159. https://hdl.handle.net/21.15107/rcub_farfar_5295 .
Radović, Jelena, Milenković, Marina, Ranđelović, Vladimir, Kundaković-Vasović, Tatjana, "Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)" in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts (2019):159-159, https://hdl.handle.net/21.15107/rcub_farfar_5295 .