Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties
Само за регистроване кориснике
2021
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Liquisolid technology has gained an increased attention as a
promising approach for the improvement of bioavailability
of poorly water soluble drugs. Suitable excipients with high
surface area and porous structure are used to convert liquid
lipophilic drugs or drug solutions/suspensions to powder
suitable for filling into capsules or compression into tablets.
Spireas (1) proposed this approach and pointed out the
importance of selecting the appropriate excipients (carrier
and coating material) in optimum amounts in order to
achieve both good flowability and acceptable compaction
properties, as prerequisites for industrial application.
Compaction properties of liquisolid systems have been
recognized as particularly challenging. However, the
published results regarding compression behavior of
liquisolid systems are still very limited (2, 3).
In the present study mesoporous, amorphous silica
excipients (Syloid® XDP 3050 and XDP 3150), optimized
to be used as carriers in l...iquisolid systems, were used for
preparation of liquisolid compacts. The aim of this study
was to evaluate the influence of carrier to coating ratio and
liquid content on flowability and compaction behavior of
liquisolid systems prepared with these novel excipients.
Кључне речи:
liquisolid / elastic recovery / Syloid® XDP / detachment stress / compaction / ejection stress / tabletability / flowabilityИзвор:
12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting, 2021Издавач:
- International Association for Pharmaceutical Technology, Mainz, Germany
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- Развој производа и технологија које обезбеђују жељено ослобађање лековитих супстанци из чврстих фармацеутских облика (RS-MESTD-Technological Development (TD or TR)-34007)
Институција/група
PharmacyTY - CONF AU - Aleksić, Ivana AU - Vasiljević, Ivana AU - Glišić, Teodora AU - Cvijić, Sandra AU - Parojčić, Jelena PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5316 AB - Liquisolid technology has gained an increased attention as a promising approach for the improvement of bioavailability of poorly water soluble drugs. Suitable excipients with high surface area and porous structure are used to convert liquid lipophilic drugs or drug solutions/suspensions to powder suitable for filling into capsules or compression into tablets. Spireas (1) proposed this approach and pointed out the importance of selecting the appropriate excipients (carrier and coating material) in optimum amounts in order to achieve both good flowability and acceptable compaction properties, as prerequisites for industrial application. Compaction properties of liquisolid systems have been recognized as particularly challenging. However, the published results regarding compression behavior of liquisolid systems are still very limited (2, 3). In the present study mesoporous, amorphous silica excipients (Syloid® XDP 3050 and XDP 3150), optimized to be used as carriers in liquisolid systems, were used for preparation of liquisolid compacts. The aim of this study was to evaluate the influence of carrier to coating ratio and liquid content on flowability and compaction behavior of liquisolid systems prepared with these novel excipients. PB - International Association for Pharmaceutical Technology, Mainz, Germany C3 - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting T1 - Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties UR - https://hdl.handle.net/21.15107/rcub_farfar_5316 ER -
@conference{ author = "Aleksić, Ivana and Vasiljević, Ivana and Glišić, Teodora and Cvijić, Sandra and Parojčić, Jelena", year = "2021", abstract = "Liquisolid technology has gained an increased attention as a promising approach for the improvement of bioavailability of poorly water soluble drugs. Suitable excipients with high surface area and porous structure are used to convert liquid lipophilic drugs or drug solutions/suspensions to powder suitable for filling into capsules or compression into tablets. Spireas (1) proposed this approach and pointed out the importance of selecting the appropriate excipients (carrier and coating material) in optimum amounts in order to achieve both good flowability and acceptable compaction properties, as prerequisites for industrial application. Compaction properties of liquisolid systems have been recognized as particularly challenging. However, the published results regarding compression behavior of liquisolid systems are still very limited (2, 3). In the present study mesoporous, amorphous silica excipients (Syloid® XDP 3050 and XDP 3150), optimized to be used as carriers in liquisolid systems, were used for preparation of liquisolid compacts. The aim of this study was to evaluate the influence of carrier to coating ratio and liquid content on flowability and compaction behavior of liquisolid systems prepared with these novel excipients.", publisher = "International Association for Pharmaceutical Technology, Mainz, Germany", journal = "12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting", title = "Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties", url = "https://hdl.handle.net/21.15107/rcub_farfar_5316" }
Aleksić, I., Vasiljević, I., Glišić, T., Cvijić, S.,& Parojčić, J.. (2021). Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting International Association for Pharmaceutical Technology, Mainz, Germany.. https://hdl.handle.net/21.15107/rcub_farfar_5316
Aleksić I, Vasiljević I, Glišić T, Cvijić S, Parojčić J. Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting. 2021;. https://hdl.handle.net/21.15107/rcub_farfar_5316 .
Aleksić, Ivana, Vasiljević, Ivana, Glišić, Teodora, Cvijić, Sandra, Parojčić, Jelena, "Liquisolid systems with mesoporous silica based carriers: An investigation of flow and compaction properties" in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11th-14th May 2021, Vienna, Austria, Virtual meeting (2021), https://hdl.handle.net/21.15107/rcub_farfar_5316 .