Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk
Аутори
Vekić, JelenaStromsnes, Kristine
Mazzalai, Stefania
Zeljković, Aleksandra
Rizzo, Manfredi
Gambini, Juan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Oxidative stress is the consequence of an overproduction of reactive oxygen species (ROS) that exceeds the antioxidant defense mechanisms. Increased levels of ROS contribute to the development of cardiovascular disorders through oxidative damage to macromolecules, particularly by oxidation of plasma lipoproteins. One of the most prominent features of atherogenic dyslipidemia is plasma accumulation of small dense LDL (sdLDL) particles, characterized by an increased susceptibility to oxidation. Indeed, a considerable and diverse body of evidence from animal models and epidemiological studies was generated supporting oxidative modification of sdLDL particles as the earliest event in atherogenesis. Lipid peroxidation of LDL particles results in the formation of various bioactive species that contribute to the atherosclerotic process through different pathophysiological mechanisms, including foam cell formation, direct detrimental effects, and receptor-mediated activation of pro-inflammator...y signaling pathways. In this paper, we will discuss recent data on the pathophysiological role of oxidative stress and atherogenic dyslipidemia and their interplay in the development of atherosclerosis. In addition, a special focus will be placed on the clinical applicability of novel, promising biomarkers of these processes.
Кључне речи:
antioxidants / non-cholesterol sterols / free radicals / oxysterols / remnant lipoproteins / small dense LDLИзвор:
Biomedicines, 2023, 11, 11Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- The European Union—NextGenerationEU—MUR D.M. funds. 737/2021—research project entitled “Syndemic approach to cardiometabolic diseases during the COVID-19 era”.
DOI: 10.3390/biomedicines11112897
ISSN: 2227-9059
PubMed: 38001900
WoS: 001108154200001
Scopus: 2-s2.0-85178345938
Институција/група
PharmacyTY - JOUR AU - Vekić, Jelena AU - Stromsnes, Kristine AU - Mazzalai, Stefania AU - Zeljković, Aleksandra AU - Rizzo, Manfredi AU - Gambini, Juan PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5340 AB - Oxidative stress is the consequence of an overproduction of reactive oxygen species (ROS) that exceeds the antioxidant defense mechanisms. Increased levels of ROS contribute to the development of cardiovascular disorders through oxidative damage to macromolecules, particularly by oxidation of plasma lipoproteins. One of the most prominent features of atherogenic dyslipidemia is plasma accumulation of small dense LDL (sdLDL) particles, characterized by an increased susceptibility to oxidation. Indeed, a considerable and diverse body of evidence from animal models and epidemiological studies was generated supporting oxidative modification of sdLDL particles as the earliest event in atherogenesis. Lipid peroxidation of LDL particles results in the formation of various bioactive species that contribute to the atherosclerotic process through different pathophysiological mechanisms, including foam cell formation, direct detrimental effects, and receptor-mediated activation of pro-inflammatory signaling pathways. In this paper, we will discuss recent data on the pathophysiological role of oxidative stress and atherogenic dyslipidemia and their interplay in the development of atherosclerosis. In addition, a special focus will be placed on the clinical applicability of novel, promising biomarkers of these processes. PB - MDPI T2 - Biomedicines T1 - Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk VL - 11 IS - 11 DO - 10.3390/biomedicines11112897 ER -
@article{ author = "Vekić, Jelena and Stromsnes, Kristine and Mazzalai, Stefania and Zeljković, Aleksandra and Rizzo, Manfredi and Gambini, Juan", year = "2023", abstract = "Oxidative stress is the consequence of an overproduction of reactive oxygen species (ROS) that exceeds the antioxidant defense mechanisms. Increased levels of ROS contribute to the development of cardiovascular disorders through oxidative damage to macromolecules, particularly by oxidation of plasma lipoproteins. One of the most prominent features of atherogenic dyslipidemia is plasma accumulation of small dense LDL (sdLDL) particles, characterized by an increased susceptibility to oxidation. Indeed, a considerable and diverse body of evidence from animal models and epidemiological studies was generated supporting oxidative modification of sdLDL particles as the earliest event in atherogenesis. Lipid peroxidation of LDL particles results in the formation of various bioactive species that contribute to the atherosclerotic process through different pathophysiological mechanisms, including foam cell formation, direct detrimental effects, and receptor-mediated activation of pro-inflammatory signaling pathways. In this paper, we will discuss recent data on the pathophysiological role of oxidative stress and atherogenic dyslipidemia and their interplay in the development of atherosclerosis. In addition, a special focus will be placed on the clinical applicability of novel, promising biomarkers of these processes.", publisher = "MDPI", journal = "Biomedicines", title = "Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk", volume = "11", number = "11", doi = "10.3390/biomedicines11112897" }
Vekić, J., Stromsnes, K., Mazzalai, S., Zeljković, A., Rizzo, M.,& Gambini, J.. (2023). Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk. in Biomedicines MDPI., 11(11). https://doi.org/10.3390/biomedicines11112897
Vekić J, Stromsnes K, Mazzalai S, Zeljković A, Rizzo M, Gambini J. Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk. in Biomedicines. 2023;11(11). doi:10.3390/biomedicines11112897 .
Vekić, Jelena, Stromsnes, Kristine, Mazzalai, Stefania, Zeljković, Aleksandra, Rizzo, Manfredi, Gambini, Juan, "Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk" in Biomedicines, 11, no. 11 (2023), https://doi.org/10.3390/biomedicines11112897 . .