Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules
Само за регистроване кориснике
2004
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous determination of imatinib mesylate and of the impurity product in Glivec(R) capsules (Novartis, Switzerland). Separations were performed on a X Terra(TM) 150 mm 4.6 mm, 5 mum particle size column at 25 degreesC. The mobile phase was a mixture of methanol-water-triethylamine (25:74: 1, v/v/v) with flow rate of 1.0 ml min(-1). pH value of water-triethylamine (TEA) was adjusted to 2.4 with orthophosphoric acid before adding of methanol. UV detection was performed at 267 nm. Acetaminophen was used as an internal standard. The method was validated statistically for its selectivity, linearity, precision, accuracy and robustness. Due to its speed and accuracy, the method may be used for quality control analyses.
Кључне речи:
imatinib mesylateИзвор:
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2004, 800, 1-2, 253-258Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.jchromb.2003.10.018
ISSN: 1570-0232
PubMed: 14698262
WoS: 000187954500034
Scopus: 2-s2.0-0347415745
Институција/група
PharmacyTY - JOUR AU - Ivanović, D AU - Medenica, Mirjana AU - Jančić, Biljana AU - Malenović, Anđelija PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/544 AB - The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous determination of imatinib mesylate and of the impurity product in Glivec(R) capsules (Novartis, Switzerland). Separations were performed on a X Terra(TM) 150 mm 4.6 mm, 5 mum particle size column at 25 degreesC. The mobile phase was a mixture of methanol-water-triethylamine (25:74: 1, v/v/v) with flow rate of 1.0 ml min(-1). pH value of water-triethylamine (TEA) was adjusted to 2.4 with orthophosphoric acid before adding of methanol. UV detection was performed at 267 nm. Acetaminophen was used as an internal standard. The method was validated statistically for its selectivity, linearity, precision, accuracy and robustness. Due to its speed and accuracy, the method may be used for quality control analyses. PB - Elsevier Science BV, Amsterdam T2 - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences T1 - Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules VL - 800 IS - 1-2 SP - 253 EP - 258 DO - 10.1016/j.jchromb.2003.10.018 ER -
@article{ author = "Ivanović, D and Medenica, Mirjana and Jančić, Biljana and Malenović, Anđelija", year = "2004", abstract = "The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous determination of imatinib mesylate and of the impurity product in Glivec(R) capsules (Novartis, Switzerland). Separations were performed on a X Terra(TM) 150 mm 4.6 mm, 5 mum particle size column at 25 degreesC. The mobile phase was a mixture of methanol-water-triethylamine (25:74: 1, v/v/v) with flow rate of 1.0 ml min(-1). pH value of water-triethylamine (TEA) was adjusted to 2.4 with orthophosphoric acid before adding of methanol. UV detection was performed at 267 nm. Acetaminophen was used as an internal standard. The method was validated statistically for its selectivity, linearity, precision, accuracy and robustness. Due to its speed and accuracy, the method may be used for quality control analyses.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences", title = "Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules", volume = "800", number = "1-2", pages = "253-258", doi = "10.1016/j.jchromb.2003.10.018" }
Ivanović, D., Medenica, M., Jančić, B.,& Malenović, A.. (2004). Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences Elsevier Science BV, Amsterdam., 800(1-2), 253-258. https://doi.org/10.1016/j.jchromb.2003.10.018
Ivanović D, Medenica M, Jančić B, Malenović A. Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2004;800(1-2):253-258. doi:10.1016/j.jchromb.2003.10.018 .
Ivanović, D, Medenica, Mirjana, Jančić, Biljana, Malenović, Anđelija, "Reversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsules" in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 800, no. 1-2 (2004):253-258, https://doi.org/10.1016/j.jchromb.2003.10.018 . .