Two-step reduction of the O-methyloxime group in the antibiotic cefetamet
Само за регистроване кориснике
2001
Чланак у часопису (Објављена верзија)
Метаподаци
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Abstract
Most oximes as well as their N-alkyl and O-alkyl derivatives are electrochemically reduced in a single four-electron step to the amine. Some exceptions have been reported, where the reduction occurs in two two-electron steps. The reduction of the O-methyloxime grouping in the antibiotic cefetamet occurs at pH 5-9 in two steps, corresponding to a reduction to the imine and amine, respectively. It has been shown that the separation of the two two-electron processes is caused by differences in position and rate of establishment of acid-base equilibria resulting in protonations of the oxime and imino grouping. © 2001 Elsevier Science B.V.
Кључне речи:
Acid-base equilibria / Cefetamet / O-Alkyloximes / Oximes / Polarography / VoltammetryИзвор:
Journal of Electroanalytical Chemistry, 2001, 507, 263-267Издавач:
- Elsevier
DOI: 10.1016/S0022-0728(01)00507-1
ISSN: 0022-0728
WoS: 000170078500039
Scopus: 2-s2.0-0035854265
Институција/група
PharmacyTY - JOUR AU - Kapetanović, Vera AU - Aleksić, Mara AU - Zuman, P. PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5447 AB - Abstract Most oximes as well as their N-alkyl and O-alkyl derivatives are electrochemically reduced in a single four-electron step to the amine. Some exceptions have been reported, where the reduction occurs in two two-electron steps. The reduction of the O-methyloxime grouping in the antibiotic cefetamet occurs at pH 5-9 in two steps, corresponding to a reduction to the imine and amine, respectively. It has been shown that the separation of the two two-electron processes is caused by differences in position and rate of establishment of acid-base equilibria resulting in protonations of the oxime and imino grouping. © 2001 Elsevier Science B.V. PB - Elsevier T2 - Journal of Electroanalytical Chemistry T1 - Two-step reduction of the O-methyloxime group in the antibiotic cefetamet VL - 507 SP - 263 EP - 267 DO - 10.1016/S0022-0728(01)00507-1 ER -
@article{ author = "Kapetanović, Vera and Aleksić, Mara and Zuman, P.", year = "2001", abstract = "Abstract Most oximes as well as their N-alkyl and O-alkyl derivatives are electrochemically reduced in a single four-electron step to the amine. Some exceptions have been reported, where the reduction occurs in two two-electron steps. The reduction of the O-methyloxime grouping in the antibiotic cefetamet occurs at pH 5-9 in two steps, corresponding to a reduction to the imine and amine, respectively. It has been shown that the separation of the two two-electron processes is caused by differences in position and rate of establishment of acid-base equilibria resulting in protonations of the oxime and imino grouping. © 2001 Elsevier Science B.V.", publisher = "Elsevier", journal = "Journal of Electroanalytical Chemistry", title = "Two-step reduction of the O-methyloxime group in the antibiotic cefetamet", volume = "507", pages = "263-267", doi = "10.1016/S0022-0728(01)00507-1" }
Kapetanović, V., Aleksić, M.,& Zuman, P.. (2001). Two-step reduction of the O-methyloxime group in the antibiotic cefetamet. in Journal of Electroanalytical Chemistry Elsevier., 507, 263-267. https://doi.org/10.1016/S0022-0728(01)00507-1
Kapetanović V, Aleksić M, Zuman P. Two-step reduction of the O-methyloxime group in the antibiotic cefetamet. in Journal of Electroanalytical Chemistry. 2001;507:263-267. doi:10.1016/S0022-0728(01)00507-1 .
Kapetanović, Vera, Aleksić, Mara, Zuman, P., "Two-step reduction of the O-methyloxime group in the antibiotic cefetamet" in Journal of Electroanalytical Chemistry, 507 (2001):263-267, https://doi.org/10.1016/S0022-0728(01)00507-1 . .