Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine
Само за регистроване кориснике
2006
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Abstract
The voltammetric behavior of cefotaxime (CFX) is investigated by cyclic and square-wave voltammetry in BR buffers (pH 1.80–12.0).
Based on the cathodic reduction peak at approximately 0.5 V in BR buffer (pH 2.8 and 9.25), a robust, highly reliable square-wave
voltammetric method (SW) was developed for determination of CFX. The linearity was achieved by SW voltammetry in 7.5 · 109 M
(3.52 ng ml1
) to 1.0 · 107 M (47 ng ml1
) and from 1.2 · 107 M (56.4 ng ml1
) to 1.2 · 106 M (568.8 ng ml1
) range at pH 2.8 with
detection and quantification limits of 0.813 ng ml1 and 2.71 ng ml1
, and 12.6 ng ml1 and 42.2 ng ml1
, respectively. At pH 9.25 linear
range was obtained from 4 · 108 M (18.8 ng ml1
) to 1.6 · 107 M (75.2 ng ml1
) with detection and quantification limits of
2.947 ng ml1 and 9.82 ng ml1
. The method was applied for CFX determination in spiked humane urine sample. A detection and quantification limits of 7.2 ng ml1 and 23.9 ng ml1 were achieved for determi...nation of CFX in urine at pH 2.8 and 13.6 ng ml1 and
45.1 ng ml1 at pH 9.25. The comparative reference method was DPV. The proposed method was checked for determination of CFX
in real human urine, and selectivity of the method over the metabolites was found to be quite satisfactory.
Кључне речи:
Cefotaxime / Square-wave voltammetry / UrineИзвор:
Journal of Electroanalytical Chemistry, 2006, 593, 1-2, 258-266Издавач:
- Elsevier
Финансирање / пројекти:
- Синтеза, квантитативни односи између структуре/особина и активности, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-MPN2006-2010-142071)
DOI: 10.1016/j.jelechem.2006.06.011
ISSN: 0022-0728
WoS: 000239295900031
Scopus: 2-s2.0-33745856584
Институција/група
PharmacyTY - JOUR AU - Aleksić, Mara M. AU - Kapetanović, Vera PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5468 AB - Abstract The voltammetric behavior of cefotaxime (CFX) is investigated by cyclic and square-wave voltammetry in BR buffers (pH 1.80–12.0). Based on the cathodic reduction peak at approximately 0.5 V in BR buffer (pH 2.8 and 9.25), a robust, highly reliable square-wave voltammetric method (SW) was developed for determination of CFX. The linearity was achieved by SW voltammetry in 7.5 · 109 M (3.52 ng ml1 ) to 1.0 · 107 M (47 ng ml1 ) and from 1.2 · 107 M (56.4 ng ml1 ) to 1.2 · 106 M (568.8 ng ml1 ) range at pH 2.8 with detection and quantification limits of 0.813 ng ml1 and 2.71 ng ml1 , and 12.6 ng ml1 and 42.2 ng ml1 , respectively. At pH 9.25 linear range was obtained from 4 · 108 M (18.8 ng ml1 ) to 1.6 · 107 M (75.2 ng ml1 ) with detection and quantification limits of 2.947 ng ml1 and 9.82 ng ml1 . The method was applied for CFX determination in spiked humane urine sample. A detection and quantification limits of 7.2 ng ml1 and 23.9 ng ml1 were achieved for determination of CFX in urine at pH 2.8 and 13.6 ng ml1 and 45.1 ng ml1 at pH 9.25. The comparative reference method was DPV. The proposed method was checked for determination of CFX in real human urine, and selectivity of the method over the metabolites was found to be quite satisfactory. PB - Elsevier T2 - Journal of Electroanalytical Chemistry T1 - Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine VL - 593 IS - 1-2 SP - 258 EP - 266 DO - 10.1016/j.jelechem.2006.06.011 ER -
@article{ author = "Aleksić, Mara M. and Kapetanović, Vera", year = "2006", abstract = "Abstract The voltammetric behavior of cefotaxime (CFX) is investigated by cyclic and square-wave voltammetry in BR buffers (pH 1.80–12.0). Based on the cathodic reduction peak at approximately 0.5 V in BR buffer (pH 2.8 and 9.25), a robust, highly reliable square-wave voltammetric method (SW) was developed for determination of CFX. The linearity was achieved by SW voltammetry in 7.5 · 109 M (3.52 ng ml1 ) to 1.0 · 107 M (47 ng ml1 ) and from 1.2 · 107 M (56.4 ng ml1 ) to 1.2 · 106 M (568.8 ng ml1 ) range at pH 2.8 with detection and quantification limits of 0.813 ng ml1 and 2.71 ng ml1 , and 12.6 ng ml1 and 42.2 ng ml1 , respectively. At pH 9.25 linear range was obtained from 4 · 108 M (18.8 ng ml1 ) to 1.6 · 107 M (75.2 ng ml1 ) with detection and quantification limits of 2.947 ng ml1 and 9.82 ng ml1 . The method was applied for CFX determination in spiked humane urine sample. A detection and quantification limits of 7.2 ng ml1 and 23.9 ng ml1 were achieved for determination of CFX in urine at pH 2.8 and 13.6 ng ml1 and 45.1 ng ml1 at pH 9.25. The comparative reference method was DPV. The proposed method was checked for determination of CFX in real human urine, and selectivity of the method over the metabolites was found to be quite satisfactory.", publisher = "Elsevier", journal = "Journal of Electroanalytical Chemistry", title = "Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine", volume = "593", number = "1-2", pages = "258-266", doi = "10.1016/j.jelechem.2006.06.011" }
Aleksić, M. M.,& Kapetanović, V.. (2006). Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine. in Journal of Electroanalytical Chemistry Elsevier., 593(1-2), 258-266. https://doi.org/10.1016/j.jelechem.2006.06.011
Aleksić MM, Kapetanović V. Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine. in Journal of Electroanalytical Chemistry. 2006;593(1-2):258-266. doi:10.1016/j.jelechem.2006.06.011 .
Aleksić, Mara M., Kapetanović, Vera, "Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine" in Journal of Electroanalytical Chemistry, 593, no. 1-2 (2006):258-266, https://doi.org/10.1016/j.jelechem.2006.06.011 . .